Physical activity is associated with reduced left ventricular mass in obese and hypertensive African Americans

Daisuke Kamimura, Paul D. Loprinzi, Wanmei Wang, Takeki Suzuki, Kenneth R. Butler, Thomas H. Mosley, Michael E. Hall

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Physical activity (PA) has been associated with decreased left ventricular (LV) hypertrophy in previous studies. However, little is known about the relationship between PA and LV structure and factors which influence this relationship among African Americans. METHODS: We evaluated 1,300 African Americans with preserved LV ejection fraction (EF > 50%) from the Genetic Epidemiology Network of Arteriopathy (GENOA) Study (mean age 62.4 years, 73% women). PA index was calculated as 3 ∗ heavy activity hours + 2 ∗ moderate activity hours + slight activity hours/day. The relationship between PA index and LV structure was evaluated using generalized estimating equation. The association between PA index and LV mass index by age group, sex, body mass index (BMI), history of hypertension, diabetes or coronary heart disease, estimated glomerular filtration rate, and current smoking status were plotted. RESULTS: After adjustment for these factors, higher PA index was independently associated with lower LV mass index (P < 0.05). There were significant interactions between PA index and obesity (BMI ≥ 30) and history of hypertension on LV mass index (P for interaction <0.05, for both). Higher PA index was associated with lower LV mass index more in obese or hypertensive participants compared with nonobese or nonhypertensive participants. CONCLUSIONS: Higher PA index was associated with reduced LV hypertrophy in obese and hypertensive African Americans. Prospective studies aimed at assessing whether increasing PA prevents LV hypertrophy and potentially reduces the risk of heart failure in these at risk groups are warranted.

Original languageEnglish (US)
Pages (from-to)617-623
Number of pages7
JournalAmerican Journal of Hypertension
Volume30
Issue number6
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

African Americans
Exercise
Left Ventricular Hypertrophy
Body Mass Index
Hypertension
Molecular Epidemiology
Glomerular Filtration Rate
Stroke Volume
Coronary Disease
Heart Failure
Age Groups
Obesity
Smoking
Prospective Studies

Keywords

  • Blood pressure
  • Hypertension
  • LV hypertrophy
  • LV mass index
  • Physical activity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Physical activity is associated with reduced left ventricular mass in obese and hypertensive African Americans. / Kamimura, Daisuke; Loprinzi, Paul D.; Wang, Wanmei; Suzuki, Takeki; Butler, Kenneth R.; Mosley, Thomas H.; Hall, Michael E.

In: American Journal of Hypertension, Vol. 30, No. 6, 01.01.2017, p. 617-623.

Research output: Contribution to journalArticle

Kamimura, Daisuke ; Loprinzi, Paul D. ; Wang, Wanmei ; Suzuki, Takeki ; Butler, Kenneth R. ; Mosley, Thomas H. ; Hall, Michael E. / Physical activity is associated with reduced left ventricular mass in obese and hypertensive African Americans. In: American Journal of Hypertension. 2017 ; Vol. 30, No. 6. pp. 617-623.
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