Physical activity, sedentary behavior, and leukocyte telomere length in women

Mengmeng Du, Jennifer Prescott, Peter Kraft, Jiali Han, Edward Giovannucci, Susan E. Hankinson, Immaculata De Vivo

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Leukocyte telomere length (LTL) is a potential indicator of cellular aging; however, its relation to physical activity and sedentary behavior is unclear. The authors examined cross-sectionally associations among activity, sedentary behavior, and LTL among 7,813 women aged 43-70 years in the Nurses' Health Study. Participants self-reported activity by questionnaire in 1988 and 1992 and sedentary behavior in 1992. Telomere length in peripheral blood leukocytes, collected in 1989-1990, was measured by quantitative polymerase chain reaction. The least-squares mean telomere length (z-score) was calculated after adjustment for age and other potential confounders. For total activity, moderately or highly active women had a 0.07-standard deviation (SD) increase in LTL (2-sided P trend = 0.02) compared with those least active. Greater moderate- or vigorous-intensity activity was also associated with increased LTL (SD = 0.11 for 2-4 vs. <1 hour/week and 0.04 for ≥7 vs. <1 hour/week; 2-sided P trend = 0.02). Specifically, calisthenics or aerobics was associated with increased LTL (SD = 0.10 for ≥2.5 vs. 0 hours/week; 2-sided P trend = 0.04). Associations remained after adjustment for body mass index. Other specific activities and sitting were unassociated with LTL. Although associations were modest, these findings suggest that even moderate amounts of activity may be associated with longer telomeres, warranting further investigation in large prospective studies.

Original languageEnglish (US)
Pages (from-to)414-422
Number of pages9
JournalAmerican Journal of Epidemiology
Volume175
Issue number5
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

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Telomere
Leukocytes
Exercise
Gymnastics
Cell Aging
Least-Squares Analysis
Body Mass Index
Nurses
Prospective Studies
Polymerase Chain Reaction
Health

Keywords

  • biological markers
  • cohort studies
  • epidemiology
  • exercise
  • physical activity
  • sedentary lifestyle
  • telomere

ASJC Scopus subject areas

  • Epidemiology

Cite this

Du, M., Prescott, J., Kraft, P., Han, J., Giovannucci, E., Hankinson, S. E., & De Vivo, I. (2012). Physical activity, sedentary behavior, and leukocyte telomere length in women. American Journal of Epidemiology, 175(5), 414-422. https://doi.org/10.1093/aje/kwr330

Physical activity, sedentary behavior, and leukocyte telomere length in women. / Du, Mengmeng; Prescott, Jennifer; Kraft, Peter; Han, Jiali; Giovannucci, Edward; Hankinson, Susan E.; De Vivo, Immaculata.

In: American Journal of Epidemiology, Vol. 175, No. 5, 01.03.2012, p. 414-422.

Research output: Contribution to journalArticle

Du, M, Prescott, J, Kraft, P, Han, J, Giovannucci, E, Hankinson, SE & De Vivo, I 2012, 'Physical activity, sedentary behavior, and leukocyte telomere length in women', American Journal of Epidemiology, vol. 175, no. 5, pp. 414-422. https://doi.org/10.1093/aje/kwr330
Du, Mengmeng ; Prescott, Jennifer ; Kraft, Peter ; Han, Jiali ; Giovannucci, Edward ; Hankinson, Susan E. ; De Vivo, Immaculata. / Physical activity, sedentary behavior, and leukocyte telomere length in women. In: American Journal of Epidemiology. 2012 ; Vol. 175, No. 5. pp. 414-422.
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