Physical and mental quality of life in chronic pancreatitis: A case-control study from the north american pancreatitis study 2 cohort

Stephen T. Amann, Dhiraj Yadav, M. Micheal Barmada, Michael O'connell, Elizabeth D. Kennard, Michelle Anderson, John Baillie, Stuart Sherman, Joseph Romagnuolo, Robert H. Hawes, Samer Alkaade, Randall E. Brand, Michele D. Lewis, Timothy B. Gardner, Andres Gelrud, Mary E. Money, Peter A. Banks, Adam Slivka, David C. Whitcomb

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Objective: The objective of this study was to define the quality of life (QOL) in patients with chronic pancreatitis (CP). METHODS: We studied 443 well-phenotyped CP subjects and 611 control subjects prospectively enrolled from 20 US centers between 2000 and 2006 in the North American Pancreatitis Study 2. Responses to the SF-12 questionnaire were used to calculate the mental (MCS) and physical component summary scores (PCS) with norm-based scoring (normal ≥50). Quality of life in CP subjects was compared with control subjects after controlling for demographic factors, drinking history, smoking, and medical conditions. Quality of life in CP was also compared with known scores for several chronic conditions. RESULTS: Both PCS (38 [SD, 11.5] vs 52 [SD, 9.4]) and MCS (44 [SD, 11.5] vs 51 [SD, 9.2]) were significantly lower in CP compared with control subjects (P < 0.001). On multivariable analyses, compared with control subjects, a profound decrease in physical QOL (PCS 12.02 points lower) and a clinically significant decrease in mental QOL (MCS 4.24 points lower) was seen due to CP. Quality of life in CP was similar to (heart, kidney, liver, lung disease) or worse than (nonskin cancers, diabetes mellitus, hypertension, rheumatoid arthritis) other chronic conditions. CONCLUSIONS: The impact of CP on QOL appears substantial. The QOL in CP subjects appears to be worse or similar to the QOL of many other chronic conditions.

Original languageEnglish
Pages (from-to)293-300
Number of pages8
JournalPancreas
Volume42
Issue number2
DOIs
StatePublished - Mar 2013

Fingerprint

Chronic Pancreatitis
Pancreatitis
Case-Control Studies
Cohort Studies
Quality of Life
Lung Diseases
Drinking
Liver Diseases
Rheumatoid Arthritis
Diabetes Mellitus
Smoking
Demography
Hypertension
Kidney

Keywords

  • chronic pancreatitis
  • prospective
  • quality of life
  • SF-12

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Amann, S. T., Yadav, D., Barmada, M. M., O'connell, M., Kennard, E. D., Anderson, M., ... Whitcomb, D. C. (2013). Physical and mental quality of life in chronic pancreatitis: A case-control study from the north american pancreatitis study 2 cohort. Pancreas, 42(2), 293-300. https://doi.org/10.1097/MPA.0b013e31826532e7

Physical and mental quality of life in chronic pancreatitis : A case-control study from the north american pancreatitis study 2 cohort. / Amann, Stephen T.; Yadav, Dhiraj; Barmada, M. Micheal; O'connell, Michael; Kennard, Elizabeth D.; Anderson, Michelle; Baillie, John; Sherman, Stuart; Romagnuolo, Joseph; Hawes, Robert H.; Alkaade, Samer; Brand, Randall E.; Lewis, Michele D.; Gardner, Timothy B.; Gelrud, Andres; Money, Mary E.; Banks, Peter A.; Slivka, Adam; Whitcomb, David C.

In: Pancreas, Vol. 42, No. 2, 03.2013, p. 293-300.

Research output: Contribution to journalArticle

Amann, ST, Yadav, D, Barmada, MM, O'connell, M, Kennard, ED, Anderson, M, Baillie, J, Sherman, S, Romagnuolo, J, Hawes, RH, Alkaade, S, Brand, RE, Lewis, MD, Gardner, TB, Gelrud, A, Money, ME, Banks, PA, Slivka, A & Whitcomb, DC 2013, 'Physical and mental quality of life in chronic pancreatitis: A case-control study from the north american pancreatitis study 2 cohort', Pancreas, vol. 42, no. 2, pp. 293-300. https://doi.org/10.1097/MPA.0b013e31826532e7
Amann, Stephen T. ; Yadav, Dhiraj ; Barmada, M. Micheal ; O'connell, Michael ; Kennard, Elizabeth D. ; Anderson, Michelle ; Baillie, John ; Sherman, Stuart ; Romagnuolo, Joseph ; Hawes, Robert H. ; Alkaade, Samer ; Brand, Randall E. ; Lewis, Michele D. ; Gardner, Timothy B. ; Gelrud, Andres ; Money, Mary E. ; Banks, Peter A. ; Slivka, Adam ; Whitcomb, David C. / Physical and mental quality of life in chronic pancreatitis : A case-control study from the north american pancreatitis study 2 cohort. In: Pancreas. 2013 ; Vol. 42, No. 2. pp. 293-300.
@article{2f08cf5233534f0d909b6321c40ee508,
title = "Physical and mental quality of life in chronic pancreatitis: A case-control study from the north american pancreatitis study 2 cohort",
abstract = "Objective: The objective of this study was to define the quality of life (QOL) in patients with chronic pancreatitis (CP). METHODS: We studied 443 well-phenotyped CP subjects and 611 control subjects prospectively enrolled from 20 US centers between 2000 and 2006 in the North American Pancreatitis Study 2. Responses to the SF-12 questionnaire were used to calculate the mental (MCS) and physical component summary scores (PCS) with norm-based scoring (normal ≥50). Quality of life in CP subjects was compared with control subjects after controlling for demographic factors, drinking history, smoking, and medical conditions. Quality of life in CP was also compared with known scores for several chronic conditions. RESULTS: Both PCS (38 [SD, 11.5] vs 52 [SD, 9.4]) and MCS (44 [SD, 11.5] vs 51 [SD, 9.2]) were significantly lower in CP compared with control subjects (P < 0.001). On multivariable analyses, compared with control subjects, a profound decrease in physical QOL (PCS 12.02 points lower) and a clinically significant decrease in mental QOL (MCS 4.24 points lower) was seen due to CP. Quality of life in CP was similar to (heart, kidney, liver, lung disease) or worse than (nonskin cancers, diabetes mellitus, hypertension, rheumatoid arthritis) other chronic conditions. CONCLUSIONS: The impact of CP on QOL appears substantial. The QOL in CP subjects appears to be worse or similar to the QOL of many other chronic conditions.",
keywords = "chronic pancreatitis, prospective, quality of life, SF-12",
author = "Amann, {Stephen T.} and Dhiraj Yadav and Barmada, {M. Micheal} and Michael O'connell and Kennard, {Elizabeth D.} and Michelle Anderson and John Baillie and Stuart Sherman and Joseph Romagnuolo and Hawes, {Robert H.} and Samer Alkaade and Brand, {Randall E.} and Lewis, {Michele D.} and Gardner, {Timothy B.} and Andres Gelrud and Money, {Mary E.} and Banks, {Peter A.} and Adam Slivka and Whitcomb, {David C.}",
year = "2013",
month = "3",
doi = "10.1097/MPA.0b013e31826532e7",
language = "English",
volume = "42",
pages = "293--300",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Physical and mental quality of life in chronic pancreatitis

T2 - A case-control study from the north american pancreatitis study 2 cohort

AU - Amann, Stephen T.

AU - Yadav, Dhiraj

AU - Barmada, M. Micheal

AU - O'connell, Michael

AU - Kennard, Elizabeth D.

AU - Anderson, Michelle

AU - Baillie, John

AU - Sherman, Stuart

AU - Romagnuolo, Joseph

AU - Hawes, Robert H.

AU - Alkaade, Samer

AU - Brand, Randall E.

AU - Lewis, Michele D.

AU - Gardner, Timothy B.

AU - Gelrud, Andres

AU - Money, Mary E.

AU - Banks, Peter A.

AU - Slivka, Adam

AU - Whitcomb, David C.

PY - 2013/3

Y1 - 2013/3

N2 - Objective: The objective of this study was to define the quality of life (QOL) in patients with chronic pancreatitis (CP). METHODS: We studied 443 well-phenotyped CP subjects and 611 control subjects prospectively enrolled from 20 US centers between 2000 and 2006 in the North American Pancreatitis Study 2. Responses to the SF-12 questionnaire were used to calculate the mental (MCS) and physical component summary scores (PCS) with norm-based scoring (normal ≥50). Quality of life in CP subjects was compared with control subjects after controlling for demographic factors, drinking history, smoking, and medical conditions. Quality of life in CP was also compared with known scores for several chronic conditions. RESULTS: Both PCS (38 [SD, 11.5] vs 52 [SD, 9.4]) and MCS (44 [SD, 11.5] vs 51 [SD, 9.2]) were significantly lower in CP compared with control subjects (P < 0.001). On multivariable analyses, compared with control subjects, a profound decrease in physical QOL (PCS 12.02 points lower) and a clinically significant decrease in mental QOL (MCS 4.24 points lower) was seen due to CP. Quality of life in CP was similar to (heart, kidney, liver, lung disease) or worse than (nonskin cancers, diabetes mellitus, hypertension, rheumatoid arthritis) other chronic conditions. CONCLUSIONS: The impact of CP on QOL appears substantial. The QOL in CP subjects appears to be worse or similar to the QOL of many other chronic conditions.

AB - Objective: The objective of this study was to define the quality of life (QOL) in patients with chronic pancreatitis (CP). METHODS: We studied 443 well-phenotyped CP subjects and 611 control subjects prospectively enrolled from 20 US centers between 2000 and 2006 in the North American Pancreatitis Study 2. Responses to the SF-12 questionnaire were used to calculate the mental (MCS) and physical component summary scores (PCS) with norm-based scoring (normal ≥50). Quality of life in CP subjects was compared with control subjects after controlling for demographic factors, drinking history, smoking, and medical conditions. Quality of life in CP was also compared with known scores for several chronic conditions. RESULTS: Both PCS (38 [SD, 11.5] vs 52 [SD, 9.4]) and MCS (44 [SD, 11.5] vs 51 [SD, 9.2]) were significantly lower in CP compared with control subjects (P < 0.001). On multivariable analyses, compared with control subjects, a profound decrease in physical QOL (PCS 12.02 points lower) and a clinically significant decrease in mental QOL (MCS 4.24 points lower) was seen due to CP. Quality of life in CP was similar to (heart, kidney, liver, lung disease) or worse than (nonskin cancers, diabetes mellitus, hypertension, rheumatoid arthritis) other chronic conditions. CONCLUSIONS: The impact of CP on QOL appears substantial. The QOL in CP subjects appears to be worse or similar to the QOL of many other chronic conditions.

KW - chronic pancreatitis

KW - prospective

KW - quality of life

KW - SF-12

UR - http://www.scopus.com/inward/record.url?scp=84874113455&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874113455&partnerID=8YFLogxK

U2 - 10.1097/MPA.0b013e31826532e7

DO - 10.1097/MPA.0b013e31826532e7

M3 - Article

C2 - 23357924

AN - SCOPUS:84874113455

VL - 42

SP - 293

EP - 300

JO - Pancreas

JF - Pancreas

SN - 0885-3177

IS - 2

ER -