Physical mapping of the 5 Mb D9S196-D9S180 interval harboring the basal cell nevus syndrome gene and localization of six genes in this region

Jingwu Xie, Anthony Quinn, Xiaoli Zhang, John Bare, Alana Rothman, Colin Collins, Steven Cutone, Marc Rutter, Mary Kay McCormick, Ervin Epstein

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The basal cell nevus syndrome (Gorlin syndrome) is characterized by multiple basal cell carcinomas and diverse developmental defects. The gene responsible for this syndrome has been mapped previously to a 2 cM interval between D9S196 and D9S180 at 9q22.3, and very recently mutations of a candidate gene in this region-the human homolog of the Drosophila patched gene-have been identified. We report here on physical mapping studies integrating a contig of yeast artificial chromosomes and bacterial artificial chromosomes with a long-range map spanning approximately 5 Mb between the recombination-determined flanking markers. Six genes have been mapped to this interval.

Original languageEnglish (US)
Pages (from-to)305-309
Number of pages5
JournalGenes Chromosomes and Cancer
Volume18
Issue number4
DOIs
StatePublished - Apr 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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