Physician-reported benefits and barriers to clinical implementation of genomic medicine: A multi-site ignite-network survey

Aniwaa Owusu Obeng, Kezhen Fei, Kenneth Levy, Amanda R. Elsey, Toni I. Pollin, Andrea H. Ramirez, Kristin W. Weitzel, Carol R. Horowitz

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Genetic medicine is one of the key components of personalized medicine, but adoption in clinical practice is still limited. To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice. These responses were also analyzed in comparison to the type of study occurring at the physicians’ institution (pharmacogenetics versus disease genetics). The majority believed that genetic testing is clinically useful; however, only a third believed that they had obtained adequate training to care for genetically “high-risk” patients. Physicians involved in pharmacogenetics initiatives were more favorable towards genetic testing applications; they found it to be clinically useful and felt more prepared and confident in their abilities to adopt it into their practice in comparison to those participating in disease genetics initiatives. These results suggest that investigators should explore which attributes of clinical pharmacogenetics (such as the use of simplified genetics-guided recommendations) can be implemented to improve attitudes and preparedness to implement disease genetics in care. Most physicians felt unprepared to use genetic information in their practice; accordingly, major steps should be taken to develop effective clinical tools and training strategies for physicians.

Original languageEnglish (US)
Article number24
JournalJournal of Personalized Medicine
Volume8
Issue number3
DOIs
StatePublished - Sep 1 2018

Fingerprint

Inborn Genetic Diseases
Medicine
Pharmacogenetics
Physicians
Genetic Testing
Precision Medicine
Aptitude
Genomics
Research Personnel
Surveys and Questionnaires

Keywords

  • Barriers
  • Chronic disease
  • Clinical implementation
  • Clinical utility
  • Genetic medicine
  • Genetic testing
  • Pharmacogenetics
  • Physician attitudes
  • Physician education

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Physician-reported benefits and barriers to clinical implementation of genomic medicine : A multi-site ignite-network survey. / Obeng, Aniwaa Owusu; Fei, Kezhen; Levy, Kenneth; Elsey, Amanda R.; Pollin, Toni I.; Ramirez, Andrea H.; Weitzel, Kristin W.; Horowitz, Carol R.

In: Journal of Personalized Medicine, Vol. 8, No. 3, 24, 01.09.2018.

Research output: Contribution to journalArticle

Obeng, Aniwaa Owusu ; Fei, Kezhen ; Levy, Kenneth ; Elsey, Amanda R. ; Pollin, Toni I. ; Ramirez, Andrea H. ; Weitzel, Kristin W. ; Horowitz, Carol R. / Physician-reported benefits and barriers to clinical implementation of genomic medicine : A multi-site ignite-network survey. In: Journal of Personalized Medicine. 2018 ; Vol. 8, No. 3.
@article{103f70139d544e3faf4dd156956664d6,
title = "Physician-reported benefits and barriers to clinical implementation of genomic medicine: A multi-site ignite-network survey",
abstract = "Genetic medicine is one of the key components of personalized medicine, but adoption in clinical practice is still limited. To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice. These responses were also analyzed in comparison to the type of study occurring at the physicians’ institution (pharmacogenetics versus disease genetics). The majority believed that genetic testing is clinically useful; however, only a third believed that they had obtained adequate training to care for genetically “high-risk” patients. Physicians involved in pharmacogenetics initiatives were more favorable towards genetic testing applications; they found it to be clinically useful and felt more prepared and confident in their abilities to adopt it into their practice in comparison to those participating in disease genetics initiatives. These results suggest that investigators should explore which attributes of clinical pharmacogenetics (such as the use of simplified genetics-guided recommendations) can be implemented to improve attitudes and preparedness to implement disease genetics in care. Most physicians felt unprepared to use genetic information in their practice; accordingly, major steps should be taken to develop effective clinical tools and training strategies for physicians.",
keywords = "Barriers, Chronic disease, Clinical implementation, Clinical utility, Genetic medicine, Genetic testing, Pharmacogenetics, Physician attitudes, Physician education",
author = "Obeng, {Aniwaa Owusu} and Kezhen Fei and Kenneth Levy and Elsey, {Amanda R.} and Pollin, {Toni I.} and Ramirez, {Andrea H.} and Weitzel, {Kristin W.} and Horowitz, {Carol R.}",
year = "2018",
month = "9",
day = "1",
doi = "10.3390/jpm8030024",
language = "English (US)",
volume = "8",
journal = "Journal of Personalized Medicine",
issn = "2075-4426",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

TY - JOUR

T1 - Physician-reported benefits and barriers to clinical implementation of genomic medicine

T2 - A multi-site ignite-network survey

AU - Obeng, Aniwaa Owusu

AU - Fei, Kezhen

AU - Levy, Kenneth

AU - Elsey, Amanda R.

AU - Pollin, Toni I.

AU - Ramirez, Andrea H.

AU - Weitzel, Kristin W.

AU - Horowitz, Carol R.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Genetic medicine is one of the key components of personalized medicine, but adoption in clinical practice is still limited. To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice. These responses were also analyzed in comparison to the type of study occurring at the physicians’ institution (pharmacogenetics versus disease genetics). The majority believed that genetic testing is clinically useful; however, only a third believed that they had obtained adequate training to care for genetically “high-risk” patients. Physicians involved in pharmacogenetics initiatives were more favorable towards genetic testing applications; they found it to be clinically useful and felt more prepared and confident in their abilities to adopt it into their practice in comparison to those participating in disease genetics initiatives. These results suggest that investigators should explore which attributes of clinical pharmacogenetics (such as the use of simplified genetics-guided recommendations) can be implemented to improve attitudes and preparedness to implement disease genetics in care. Most physicians felt unprepared to use genetic information in their practice; accordingly, major steps should be taken to develop effective clinical tools and training strategies for physicians.

AB - Genetic medicine is one of the key components of personalized medicine, but adoption in clinical practice is still limited. To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice. These responses were also analyzed in comparison to the type of study occurring at the physicians’ institution (pharmacogenetics versus disease genetics). The majority believed that genetic testing is clinically useful; however, only a third believed that they had obtained adequate training to care for genetically “high-risk” patients. Physicians involved in pharmacogenetics initiatives were more favorable towards genetic testing applications; they found it to be clinically useful and felt more prepared and confident in their abilities to adopt it into their practice in comparison to those participating in disease genetics initiatives. These results suggest that investigators should explore which attributes of clinical pharmacogenetics (such as the use of simplified genetics-guided recommendations) can be implemented to improve attitudes and preparedness to implement disease genetics in care. Most physicians felt unprepared to use genetic information in their practice; accordingly, major steps should be taken to develop effective clinical tools and training strategies for physicians.

KW - Barriers

KW - Chronic disease

KW - Clinical implementation

KW - Clinical utility

KW - Genetic medicine

KW - Genetic testing

KW - Pharmacogenetics

KW - Physician attitudes

KW - Physician education

UR - http://www.scopus.com/inward/record.url?scp=85054713893&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054713893&partnerID=8YFLogxK

U2 - 10.3390/jpm8030024

DO - 10.3390/jpm8030024

M3 - Article

AN - SCOPUS:85054713893

VL - 8

JO - Journal of Personalized Medicine

JF - Journal of Personalized Medicine

SN - 2075-4426

IS - 3

M1 - 24

ER -