Physiologic, bronchoscopic, and bronchoalveolar lavage fluid findings in young children with recurrent wheeze and cough

John Saito, William T. Harris, Jonathan Gelfond, Terry L. Noah, Margaret W. Leigh, Robin Johnson, Stephanie Davis

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Assessing airway disease in young children with wheeze and/or cough is challenging. We conducted a prospective, descriptive study of lung function in children 0.5), -2.28 for forced expiratory flows at 75% of forced vital capacity (FVC) (FEF75), -2.25 for forced expiratory flows between 25-75% of FVC (FEF25-75), 2.53 for functional residual capacity (FRC), and 2.23 for residual volume divided by total lung capacity (RV/TLC). Younger, shorter children had markedly depressed FEF75 and FEF25-75 Z-scores (P = 0.002 and P = 2) had no evidence of chest radiograph hyperinflation. We conclude that in this population, plethysmography and RVRTC techniques are useful in identifying severity of hyperinflation and airflow obstruction, and we hypothesize that younger children may have relatively small airways caliber, significantly limiting airflow, and thus impairing secretion clearance and predisposing to lower airway infection.

Original languageEnglish (US)
Pages (from-to)709-719
Number of pages11
JournalPediatric Pulmonology
Volume41
Issue number8
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Bronchoalveolar Lavage Fluid
Cough
Vital Capacity
Total Lung Capacity
Functional Residual Capacity
Residual Volume
Plethysmography
Thorax
Prospective Studies
Lung
Infection
Population

Keywords

  • Airway inflammation
  • Bronchitis
  • Bronchoscopy
  • Forced expiratory flows
  • Infant pulmonary function tests
  • Plethysmography
  • Raised volume technique

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Physiologic, bronchoscopic, and bronchoalveolar lavage fluid findings in young children with recurrent wheeze and cough. / Saito, John; Harris, William T.; Gelfond, Jonathan; Noah, Terry L.; Leigh, Margaret W.; Johnson, Robin; Davis, Stephanie.

In: Pediatric Pulmonology, Vol. 41, No. 8, 08.2006, p. 709-719.

Research output: Contribution to journalArticle

Saito, John ; Harris, William T. ; Gelfond, Jonathan ; Noah, Terry L. ; Leigh, Margaret W. ; Johnson, Robin ; Davis, Stephanie. / Physiologic, bronchoscopic, and bronchoalveolar lavage fluid findings in young children with recurrent wheeze and cough. In: Pediatric Pulmonology. 2006 ; Vol. 41, No. 8. pp. 709-719.
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