Physiologic findings in children previously ventilator dependent at home due to bronchopulmonary dysplasia

A. Ioana Cristea, Veda L. Ackerman, Nancy L. Swigonski, Zhangsheng Yu, James E. Slaven, Stephanie D. Davis

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Introduction Bronchopulmonary dysplasia (BPD) is the primary respiratory complication of premature birth. Some preterm newborns develop chronic respiratory failure, requiring home ventilator support. While physiologic measures have been described for prematurely born children, little is known about spirometric indices in patients with severe BPD who were previously ventilator dependent at home. Methods We retrospectively reviewed medical charts of patients with severe BPD who were ventilator dependent at home. We excluded patients with other comorbidities that could contribute to the severity of BPD. Spirometry was performed when the patient was able to follow commands. Results Between 1984 and 2012, within our severe BPD cohort who previously required home ventilator support, 19 patients were able to perform reproducible spirometry meeting ATS/ERS acceptability criteria. Ten (52.6%) were females, 13 (68.4%) were Caucasians. Mean age at liberation from ventilation was 2.4 years (C.I. 2.0, 2.9) and at decannulation was 3.5 years (C.I. 2.9, 4.0); median age at first reproducible spirometry measurement was 6.6 years (IQR: 4.9, 8.3). Spirometry results revealed significant airway obstruction, as demonstrated by Z-scores values of -1.5 (C.I. -2.5, -0.4) for FVC, -2.7 (C.I. -3.3, -1.9) for FEV1, and -3.6 (C.I. -4.3, -2.9) for FEF25-75. More so, serial spirometric measurements' slopes revealed that the airway obstruction remained static over time (FEV1 slope: -0.07, P-value: 0.2624; FVC slope: -0.01, P-value: 0.9064; and FEF25-75: 0.0, P-value: 0.8532). Conclusions Extreme prematurity associated with severe BPD requiring home ventilator support carries significant risks of morbidity. These patients had substantially diminished respiratory function reflecting airflow abnormalities that remained static over time. Pediatr Pulmonol. 2015; 50:1113-1118.

Original languageEnglish (US)
Pages (from-to)1113-1118
Number of pages6
JournalPediatric pulmonology
Volume50
Issue number11
DOIs
StatePublished - Nov 2015

Keywords

  • pulmonary function testing
  • spirometry
  • tracheostomy
  • ventilator-dependent children

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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