Physiological and pathological roles of parathyroid hormone-related peptide

Theresa Guise, Gregory R. Mundy

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Parathyroid hormone-related peptide was originally identified as a tumor-produced factor that mediated malignancy-associated hypercalcemia by binding to the common parathyroid hormone/parathyroid hormone-related peptide receptor to stimulate osteoclastic bone resorption and renal tubular resorption of calcium. Its role as a humoral factor in hypercalcemia of malignancy is well established, and recent work has demonstrated its importance as a tumor-produced factor in the pathogenesis of bone metastasis. Besides these cancer-related functions, work in the past decade has clearly established that parathyroid hormone-related peptide has many important functions in normal physiology related to growth and development, reproductive function and smooth muscle relaxation. Many other physiological functions are also being attributed to this Versatile peptide. An understanding of these functions in malignancy and normal physiology should lead to innovative therapy for malignancy as well as other disorders not previously related to calcium homeostasis.

Original languageEnglish (US)
Pages (from-to)307-315
Number of pages9
JournalCurrent Opinion in Nephrology and Hypertension
Volume5
Issue number4
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Parathyroid Hormone-Related Protein
Neoplasms
Hypercalcemia
Parathyroid Hormone Receptor Type 1
Calcium
Investigational Therapies
Muscle Relaxation
Bone Resorption
Parathyroid Hormone
Growth and Development
Smooth Muscle
Homeostasis
Neoplasm Metastasis
Kidney
Bone and Bones
Peptides

ASJC Scopus subject areas

  • Nephrology
  • Internal Medicine

Cite this

Physiological and pathological roles of parathyroid hormone-related peptide. / Guise, Theresa; Mundy, Gregory R.

In: Current Opinion in Nephrology and Hypertension, Vol. 5, No. 4, 1996, p. 307-315.

Research output: Contribution to journalArticle

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