Physiologically based pharmacokinetic (PBPK) models for ethanol

Martin H. Plawecki, Jae Joon Han, Peter C. Doerschuk, Vijay A. Ramchandani, Sean J. O'Connor

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Physiologically based pharmacokinetic models have been used to describe the distribution and elimination of ethanol after intravenous administration. These models have been used to estimate the ethanol infusion profile that is sufficient for achieving a prescribed breath ethanol concentration time course in individuals, providing a useful platform for several pharmacokinetic and pharmacodynamic investigations. Mathematical foundations of these models are examined, including the derivation of an explicit set of governing equations in the form of a system of nonlinear ordinary differential equations. These equations can then be used to formulate and refine parameter identification and control strategies. Finally, a framework in which models related to this model can be constructed and analyzed is described.

Original languageEnglish (US)
Article number5
Pages (from-to)2691-2700
Number of pages10
JournalIEEE Transactions on Biomedical Engineering
Volume55
Issue number12
DOIs
StatePublished - Dec 1 2008

Fingerprint

Pharmacokinetics
Ethanol
Pharmacodynamics
Ordinary differential equations
Identification (control systems)

Keywords

  • Alcohol
  • Ethanol
  • Model
  • Pharmacokinetics
  • Physiologically based pharmacokinetic (PBPK) models
  • Physiology

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Physiologically based pharmacokinetic (PBPK) models for ethanol. / Plawecki, Martin H.; Han, Jae Joon; Doerschuk, Peter C.; Ramchandani, Vijay A.; O'Connor, Sean J.

In: IEEE Transactions on Biomedical Engineering, Vol. 55, No. 12, 5, 01.12.2008, p. 2691-2700.

Research output: Contribution to journalArticle

Plawecki, Martin H. ; Han, Jae Joon ; Doerschuk, Peter C. ; Ramchandani, Vijay A. ; O'Connor, Sean J. / Physiologically based pharmacokinetic (PBPK) models for ethanol. In: IEEE Transactions on Biomedical Engineering. 2008 ; Vol. 55, No. 12. pp. 2691-2700.
@article{b5e0696a5bcf4d758c8281a4a5587b53,
title = "Physiologically based pharmacokinetic (PBPK) models for ethanol",
abstract = "Physiologically based pharmacokinetic models have been used to describe the distribution and elimination of ethanol after intravenous administration. These models have been used to estimate the ethanol infusion profile that is sufficient for achieving a prescribed breath ethanol concentration time course in individuals, providing a useful platform for several pharmacokinetic and pharmacodynamic investigations. Mathematical foundations of these models are examined, including the derivation of an explicit set of governing equations in the form of a system of nonlinear ordinary differential equations. These equations can then be used to formulate and refine parameter identification and control strategies. Finally, a framework in which models related to this model can be constructed and analyzed is described.",
keywords = "Alcohol, Ethanol, Model, Pharmacokinetics, Physiologically based pharmacokinetic (PBPK) models, Physiology",
author = "Plawecki, {Martin H.} and Han, {Jae Joon} and Doerschuk, {Peter C.} and Ramchandani, {Vijay A.} and O'Connor, {Sean J.}",
year = "2008",
month = "12",
day = "1",
doi = "10.1109/TBME.2008.919132",
language = "English (US)",
volume = "55",
pages = "2691--2700",
journal = "IEEE Transactions on Biomedical Engineering",
issn = "0018-9294",
publisher = "IEEE Computer Society",
number = "12",

}

TY - JOUR

T1 - Physiologically based pharmacokinetic (PBPK) models for ethanol

AU - Plawecki, Martin H.

AU - Han, Jae Joon

AU - Doerschuk, Peter C.

AU - Ramchandani, Vijay A.

AU - O'Connor, Sean J.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Physiologically based pharmacokinetic models have been used to describe the distribution and elimination of ethanol after intravenous administration. These models have been used to estimate the ethanol infusion profile that is sufficient for achieving a prescribed breath ethanol concentration time course in individuals, providing a useful platform for several pharmacokinetic and pharmacodynamic investigations. Mathematical foundations of these models are examined, including the derivation of an explicit set of governing equations in the form of a system of nonlinear ordinary differential equations. These equations can then be used to formulate and refine parameter identification and control strategies. Finally, a framework in which models related to this model can be constructed and analyzed is described.

AB - Physiologically based pharmacokinetic models have been used to describe the distribution and elimination of ethanol after intravenous administration. These models have been used to estimate the ethanol infusion profile that is sufficient for achieving a prescribed breath ethanol concentration time course in individuals, providing a useful platform for several pharmacokinetic and pharmacodynamic investigations. Mathematical foundations of these models are examined, including the derivation of an explicit set of governing equations in the form of a system of nonlinear ordinary differential equations. These equations can then be used to formulate and refine parameter identification and control strategies. Finally, a framework in which models related to this model can be constructed and analyzed is described.

KW - Alcohol

KW - Ethanol

KW - Model

KW - Pharmacokinetics

KW - Physiologically based pharmacokinetic (PBPK) models

KW - Physiology

UR - http://www.scopus.com/inward/record.url?scp=58149231284&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149231284&partnerID=8YFLogxK

U2 - 10.1109/TBME.2008.919132

DO - 10.1109/TBME.2008.919132

M3 - Article

C2 - 19126448

AN - SCOPUS:58149231284

VL - 55

SP - 2691

EP - 2700

JO - IEEE Transactions on Biomedical Engineering

JF - IEEE Transactions on Biomedical Engineering

SN - 0018-9294

IS - 12

M1 - 5

ER -