Physiology and biochemistry of the kidney vacuolar H+-ATPase

Stephen L. Gluck, David M. Underhill, Masahiro Iyori, L. Shannon Holliday, Tatiana Y. Kostrominova, Beth S. Lee

Research output: Contribution to journalReview article

117 Scopus citations


Vacuolar H+-ATPases have an essential role in renal hydrogen ion secretion in the proximal tubule, collecting duct, and other segments of the nephron. Control of H+ transport is achieved by variations in the intrinsic properties of the renal H+-ATPases and by several cellular regulatory mechanisms, including redistribution of the enzyme both by vesicular traffic and regulated assembly and disassembly, and cytosolic regulatory proteins that interact directly with H+-ATPase. These mechanisms may provide a means for fine control of net acid excretion and for regulating vacuolar H+- ATPases residing on the plasma membrane independently from those in intracellular compartments.

Original languageEnglish (US)
Pages (from-to)427-445
Number of pages19
JournalAnnual Review of Physiology
StatePublished - Jan 1 1996
Externally publishedYes


  • H transport
  • collecting tubule
  • proximal tubule
  • urinary acidification

ASJC Scopus subject areas

  • Physiology

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