Physiology and biochemistry of the kidney vacuolar H+-ATPase

Stephen L. Gluck, David M. Underhill, Masahiro Iyori, L. Shannon Holliday, Tatiana Kostrominova, Beth S. Lee

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Vacuolar H+-ATPases have an essential role in renal hydrogen ion secretion in the proximal tubule, collecting duct, and other segments of the nephron. Control of H+ transport is achieved by variations in the intrinsic properties of the renal H+-ATPases and by several cellular regulatory mechanisms, including redistribution of the enzyme both by vesicular traffic and regulated assembly and disassembly, and cytosolic regulatory proteins that interact directly with H+-ATPase. These mechanisms may provide a means for fine control of net acid excretion and for regulating vacuolar H+- ATPases residing on the plasma membrane independently from those in intracellular compartments.

Original languageEnglish (US)
Pages (from-to)427-445
Number of pages19
JournalAnnual Review of Physiology
Volume58
StatePublished - 1996
Externally publishedYes

Fingerprint

Vacuolar Proton-Translocating ATPases
Proton-Translocating ATPases
Biochemistry
Kidney
Nephrons
Protons
Cell Membrane
Acids
Enzymes
Proteins

Keywords

  • collecting tubule
  • H transport
  • proximal tubule
  • urinary acidification

ASJC Scopus subject areas

  • Physiology

Cite this

Gluck, S. L., Underhill, D. M., Iyori, M., Holliday, L. S., Kostrominova, T., & Lee, B. S. (1996). Physiology and biochemistry of the kidney vacuolar H+-ATPase. Annual Review of Physiology, 58, 427-445.

Physiology and biochemistry of the kidney vacuolar H+-ATPase. / Gluck, Stephen L.; Underhill, David M.; Iyori, Masahiro; Holliday, L. Shannon; Kostrominova, Tatiana; Lee, Beth S.

In: Annual Review of Physiology, Vol. 58, 1996, p. 427-445.

Research output: Contribution to journalArticle

Gluck, SL, Underhill, DM, Iyori, M, Holliday, LS, Kostrominova, T & Lee, BS 1996, 'Physiology and biochemistry of the kidney vacuolar H+-ATPase', Annual Review of Physiology, vol. 58, pp. 427-445.
Gluck SL, Underhill DM, Iyori M, Holliday LS, Kostrominova T, Lee BS. Physiology and biochemistry of the kidney vacuolar H+-ATPase. Annual Review of Physiology. 1996;58:427-445.
Gluck, Stephen L. ; Underhill, David M. ; Iyori, Masahiro ; Holliday, L. Shannon ; Kostrominova, Tatiana ; Lee, Beth S. / Physiology and biochemistry of the kidney vacuolar H+-ATPase. In: Annual Review of Physiology. 1996 ; Vol. 58. pp. 427-445.
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