Whole body calcium and phosphate metabolisms are controlled by mechanisms at three organs: the intestine where calcium and phosphate enter the body from the diet, the kidney where calcium and phosphate are excreted, and the bone where calcium and phosphate are stored together as apatite crystals and serve both as mineral reservoirs and as structural components that provide strength to bone . The greatest stores of calcium and phosphate reside in bone, but important smaller metabolically active stores are present both outside and inside cells. Although the density and microstructure of bone reflect the availability and utilization of calcium and phosphate in the body, homeostatic mechanisms exist to protect plasma concentrations and not bones.
|Original language||English (US)|
|Title of host publication||The Physiological Basis of Metabolic Bone Disease|
|Number of pages||28|
|State||Published - Jan 1 2014|
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