Pig Liver Xenotransplantation: A Review of Progress Toward the Clinic

David K C Cooper, De Feng Dou, Kai shan Tao, Zhao xu Yang, Joseph J. Tector, Burcin Ekser

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

ABSTRACT: Experience with clinical liver xenotransplantation has largely involved the transplantation of livers from nonhuman primates. Experience with pig livers has been scarce. This brief review will be restricted to assessing the potential therapeutic impact of pig liver xenotransplantation in acute liver failure and the remaining barriers that currently do not justify clinical trials. A relatively new surgical technique of heterotopic pig liver xenotransplantation is described that might play a role in bridging a patient with acute liver failure until either the native liver recovers or a suitable liver allograft is obtained. Other topics discussed include the possible mechanisms for the development of the thrombocytopenis that rapidly occurs after pig liver xenotransplantation in a primate, the impact of pig complement on graft injury, the potential infectious risks, and potential physiologic incompatibilities between pig and human. There is cautious optimism that all of these problems can be overcome by judicious genetic manipulation of the pig. If liver graft survival could be achieved in the absence of thrombocytopenia or rejection for a period of even a few days, there may be a role for pig liver transplantation as a bridge to allotransplantation in carefully selected patients.

Original languageEnglish (US)
JournalTransplantation
DOIs
StateAccepted/In press - Jul 15 2016
Externally publishedYes

Fingerprint

Heterologous Transplantation
Swine
Liver
Acute Liver Failure
Liver Transplantation
Primates
Graft Survival
Thrombocytopenia
Allografts
Clinical Trials
Transplants
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)
  • Transplantation

Cite this

Cooper, D. K. C., Dou, D. F., Tao, K. S., Yang, Z. X., Tector, J. J., & Ekser, B. (Accepted/In press). Pig Liver Xenotransplantation: A Review of Progress Toward the Clinic. Transplantation. https://doi.org/10.1097/TP.0000000000001319

Pig Liver Xenotransplantation : A Review of Progress Toward the Clinic. / Cooper, David K C; Dou, De Feng; Tao, Kai shan; Yang, Zhao xu; Tector, Joseph J.; Ekser, Burcin.

In: Transplantation, 15.07.2016.

Research output: Contribution to journalArticle

Cooper, David K C ; Dou, De Feng ; Tao, Kai shan ; Yang, Zhao xu ; Tector, Joseph J. ; Ekser, Burcin. / Pig Liver Xenotransplantation : A Review of Progress Toward the Clinic. In: Transplantation. 2016.
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