Pilot study of erlotinib in patients with acute myeloid leukemia

S. Sayar, Magdalena Czader, Chirag Amin, Mary Cangany, Heiko Konig, Larry D. Cripe

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We conducted a pilot study to investigate clinical efficacy of tyrosine kinase inhibitor erlotinib in the treatment of acute myeloid leukemia (AML). A total of 11 patients with de novo AML were treated, including 2 with relapsed and/or refractory disease and 9 older patients with previously untreated AML. Patients with high baseline leukocyte count were excluded. Erlotinib was given orally at 150. mg per day continuously in 28-day cycles. The treatment was tolerated well, and no toxicities were observed. An initial reduction in circulating blasts, followed by disease progression, was observed in 2 patients. Nine other patients did not demonstrate any response in blood or bone marrow. Baseline and post-cycle 1 flow-cytometry were performed on bone marrow blasts to investigate signs of differentiation. No immunophenotypic changes suggestive of differentiation were observed. This pilot study did not demonstrate response to standard doses of erlotinib in patients with AML.

Original languageEnglish (US)
Pages (from-to)170-172
Number of pages3
JournalLeukemia Research
Volume39
Issue number2
DOIs
StatePublished - Feb 1 2015

Keywords

  • Acute myeloid leukemia
  • AML
  • EGFR
  • Erlotinib
  • Pilot study

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology
  • Medicine(all)

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