Pituitary macroadenoma in a patient with poems syndrome in conjunction with Castleman disease: First report of a case and review of related literature

Carolina Bruno, James Fleck, Melissa K. Cavaghan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To describe the first reported case of a patient with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) in conjunction with the endocrinologic manifestation of panhypopituitarism due to a large clinically nonfunctioning pituitary adenoma. Methods: We present the clinical, laboratory, and radiologic details of the case and review the relevant updated literature. Results: A 48-year-old man with hypopituitarism and progressive polyneuropathy presented to an outside hospital with confusion and diaphoresis. He also had diffuse lymphadenopathy, monoclonal gammopathy, and skin lesions consistent with a diagnosis of POEMS syndrome. Cytopathologic study of a lymph node showed findings consistent with Castleman disease. A large suprasellar mass was found to be the cause of the hypopituitarism. Conclusion: POEMS syndrome is a rare paraneoplastic condition, commonly associated with Castleman disease, that manifests with progressive distal polyneuropathy and a monoclonal plasma cell disorder, often accompanied by endocrinopathy, organomegaly, skin changes, sclerotic bone lesions, ascites, erythrocytosis, and thrombocytosis. Our current patient had all 5 classic features of POEMS syndrome along with some diagnostic elements of Castleman disease, sclerotic bone lesions, and thrombocytosis. To our knowledge, this is the first known reported case of a patient whose endocrinologic manifestation of POEMS syndrome was panhypopituitarism attributable to a large clinically nonfunctioning pituitary adenoma.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalEndocrine Practice
Volume16
Issue number1
DOIs
StatePublished - Jan 2010

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POEMS Syndrome
Giant Lymph Node Hyperplasia
Thrombocytosis
Hypopituitarism
Paraproteinemias
Polyneuropathies
Pituitary Neoplasms
Skin
Bone and Bones
Polycythemia
Plasma Cells
Ascites
Lymph Nodes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Pituitary macroadenoma in a patient with poems syndrome in conjunction with Castleman disease : First report of a case and review of related literature. / Bruno, Carolina; Fleck, James; Cavaghan, Melissa K.

In: Endocrine Practice, Vol. 16, No. 1, 01.2010, p. 97-101.

Research output: Contribution to journalArticle

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