Pituitary size in depression

K. Ranga Rama Krishnan, P. Murali Doraiswamy, Scott N. Lurie, Gary S. Figiel, Mustafa M. Husain, Orest Boyko, Everett H. Ellinwood, Charles B. Nemeroff

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age-and sex-matched controls. Depressed patients had significantly greater pituitary cross-sectional area (P = 0.0009) and volume (P = 0.007) than the controls. This difference was particularly prominent in elderly depressed patients compared to elderly controls. These results provide the first demonstration of structural alterations in the pituitary gland in major depression.

Original languageEnglish (US)
Pages (from-to)256-259
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume72
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

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Pituitary Gland
Magnetic resonance
Magnetic Resonance Spectroscopy
Demonstrations

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Rama Krishnan, K. R., Doraiswamy, P. M., Lurie, S. N., Figiel, G. S., Husain, M. M., Boyko, O., ... Nemeroff, C. B. (1991). Pituitary size in depression. Journal of Clinical Endocrinology and Metabolism, 72(2), 256-259. https://doi.org/10.1210/jcem-72-2-256

Pituitary size in depression. / Rama Krishnan, K. Ranga; Doraiswamy, P. Murali; Lurie, Scott N.; Figiel, Gary S.; Husain, Mustafa M.; Boyko, Orest; Ellinwood, Everett H.; Nemeroff, Charles B.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 72, No. 2, 1991, p. 256-259.

Research output: Contribution to journalArticle

Rama Krishnan, KR, Doraiswamy, PM, Lurie, SN, Figiel, GS, Husain, MM, Boyko, O, Ellinwood, EH & Nemeroff, CB 1991, 'Pituitary size in depression', Journal of Clinical Endocrinology and Metabolism, vol. 72, no. 2, pp. 256-259. https://doi.org/10.1210/jcem-72-2-256
Rama Krishnan KR, Doraiswamy PM, Lurie SN, Figiel GS, Husain MM, Boyko O et al. Pituitary size in depression. Journal of Clinical Endocrinology and Metabolism. 1991;72(2):256-259. https://doi.org/10.1210/jcem-72-2-256
Rama Krishnan, K. Ranga ; Doraiswamy, P. Murali ; Lurie, Scott N. ; Figiel, Gary S. ; Husain, Mustafa M. ; Boyko, Orest ; Ellinwood, Everett H. ; Nemeroff, Charles B. / Pituitary size in depression. In: Journal of Clinical Endocrinology and Metabolism. 1991 ; Vol. 72, No. 2. pp. 256-259.
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