Plaque and deposits in nine human stone diseases

Fredric L. Coe, Andrew Evan, James E. Lingeman, Elaine M. Worcester

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Data concerning nine forms of human stone disease, along with observations on normal people give new insights into formation of interstitial apatite plaque and intra-tubular crystal deposits. In general, across multiple disease states, one can reproduce the same relationships between plaque abundance as is seen among patients within individual disease states, so that the link between plaque and high urine calcium excretion, and low urine volume and pH seems increasingly secure. From this, one can propose a specific model of plaque formation, susceptible to experimental test. In many diseases, formation of inner medullary collecting duct and Bellini duct deposits is compatible with simple crystallization driven by urine supersaturations; this is expected in that these segments contain tubule fluid quite close in composition to final urine. But in ileostomy, small bowel disease and obesity bypass patients, crystals found in deposits are not those expected: apatite and urates in deposits, despite formation of highly acidic urine. Also, this discrepancy suggests the possibility of divergence between bulk urine pH and pH of focal collecting ducts, a new kind of possibility that is susceptible to experimental test.

Original languageEnglish
Pages (from-to)239-247
Number of pages9
JournalUrological Research
Volume38
Issue number4
DOIs
StatePublished - Aug 2010

Fingerprint

Urine
Apatites
Ileostomy
Crystallization
Uric Acid
Obesity
Calcium

Keywords

  • Apatite
  • Calcium oxalate
  • Cystine
  • Plaque
  • Stone disease
  • Urate

ASJC Scopus subject areas

  • Urology

Cite this

Plaque and deposits in nine human stone diseases. / Coe, Fredric L.; Evan, Andrew; Lingeman, James E.; Worcester, Elaine M.

In: Urological Research, Vol. 38, No. 4, 08.2010, p. 239-247.

Research output: Contribution to journalArticle

Coe, FL, Evan, A, Lingeman, JE & Worcester, EM 2010, 'Plaque and deposits in nine human stone diseases', Urological Research, vol. 38, no. 4, pp. 239-247. https://doi.org/10.1007/s00240-010-0296-z
Coe, Fredric L. ; Evan, Andrew ; Lingeman, James E. ; Worcester, Elaine M. / Plaque and deposits in nine human stone diseases. In: Urological Research. 2010 ; Vol. 38, No. 4. pp. 239-247.
@article{261ba7f002664f35ab9ad2e0e0caf851,
title = "Plaque and deposits in nine human stone diseases",
abstract = "Data concerning nine forms of human stone disease, along with observations on normal people give new insights into formation of interstitial apatite plaque and intra-tubular crystal deposits. In general, across multiple disease states, one can reproduce the same relationships between plaque abundance as is seen among patients within individual disease states, so that the link between plaque and high urine calcium excretion, and low urine volume and pH seems increasingly secure. From this, one can propose a specific model of plaque formation, susceptible to experimental test. In many diseases, formation of inner medullary collecting duct and Bellini duct deposits is compatible with simple crystallization driven by urine supersaturations; this is expected in that these segments contain tubule fluid quite close in composition to final urine. But in ileostomy, small bowel disease and obesity bypass patients, crystals found in deposits are not those expected: apatite and urates in deposits, despite formation of highly acidic urine. Also, this discrepancy suggests the possibility of divergence between bulk urine pH and pH of focal collecting ducts, a new kind of possibility that is susceptible to experimental test.",
keywords = "Apatite, Calcium oxalate, Cystine, Plaque, Stone disease, Urate",
author = "Coe, {Fredric L.} and Andrew Evan and Lingeman, {James E.} and Worcester, {Elaine M.}",
year = "2010",
month = "8",
doi = "10.1007/s00240-010-0296-z",
language = "English",
volume = "38",
pages = "239--247",
journal = "Urolithiasis",
issn = "2194-7228",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Plaque and deposits in nine human stone diseases

AU - Coe, Fredric L.

AU - Evan, Andrew

AU - Lingeman, James E.

AU - Worcester, Elaine M.

PY - 2010/8

Y1 - 2010/8

N2 - Data concerning nine forms of human stone disease, along with observations on normal people give new insights into formation of interstitial apatite plaque and intra-tubular crystal deposits. In general, across multiple disease states, one can reproduce the same relationships between plaque abundance as is seen among patients within individual disease states, so that the link between plaque and high urine calcium excretion, and low urine volume and pH seems increasingly secure. From this, one can propose a specific model of plaque formation, susceptible to experimental test. In many diseases, formation of inner medullary collecting duct and Bellini duct deposits is compatible with simple crystallization driven by urine supersaturations; this is expected in that these segments contain tubule fluid quite close in composition to final urine. But in ileostomy, small bowel disease and obesity bypass patients, crystals found in deposits are not those expected: apatite and urates in deposits, despite formation of highly acidic urine. Also, this discrepancy suggests the possibility of divergence between bulk urine pH and pH of focal collecting ducts, a new kind of possibility that is susceptible to experimental test.

AB - Data concerning nine forms of human stone disease, along with observations on normal people give new insights into formation of interstitial apatite plaque and intra-tubular crystal deposits. In general, across multiple disease states, one can reproduce the same relationships between plaque abundance as is seen among patients within individual disease states, so that the link between plaque and high urine calcium excretion, and low urine volume and pH seems increasingly secure. From this, one can propose a specific model of plaque formation, susceptible to experimental test. In many diseases, formation of inner medullary collecting duct and Bellini duct deposits is compatible with simple crystallization driven by urine supersaturations; this is expected in that these segments contain tubule fluid quite close in composition to final urine. But in ileostomy, small bowel disease and obesity bypass patients, crystals found in deposits are not those expected: apatite and urates in deposits, despite formation of highly acidic urine. Also, this discrepancy suggests the possibility of divergence between bulk urine pH and pH of focal collecting ducts, a new kind of possibility that is susceptible to experimental test.

KW - Apatite

KW - Calcium oxalate

KW - Cystine

KW - Plaque

KW - Stone disease

KW - Urate

UR - http://www.scopus.com/inward/record.url?scp=77956191912&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956191912&partnerID=8YFLogxK

U2 - 10.1007/s00240-010-0296-z

DO - 10.1007/s00240-010-0296-z

M3 - Article

VL - 38

SP - 239

EP - 247

JO - Urolithiasis

JF - Urolithiasis

SN - 2194-7228

IS - 4

ER -