Plasma 1,25-(OH)2-vitamin D concentrations and net intestinal calcium, phosphate, and magnesium absorption in humans

D. R. Wilz, R. W. Gray, Jesus Dominguez, J. Lemann

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The relationship was established between plasma concentrations of the renal hormone 1,25-(OH)2-vitamin D and net intestinal absorption of Ca, PO4, and Mg in vitamin D-replete patients eating similar diets, who had undetectable, normal or elevated plasma 1,25-(OH)2-D levels. Net intestinal CA absorption was positively correlated to plasma 1,25-(OH)2-D concentrations: percentage dietary CA absorbed = 10 + 0.17 x plasma total 1,25-(OH)2-D, pmole/liter, r = +0.58; P <0.001. By contrast, there was no significant correlation between PO4 or MG absorption and plasma 1,25-(OH)2-D concentrations. Moreover, significant quantities of PO4 and Mg were absorbed in the absence of detectable plasma 1,25-(OH)2-D. It is concluded that net intestinal Ca absorption is critically dependent upon the availability of the renal hormone 1,25-(OH)2-D in vitamin D-replete humans when dietary CA intake is normal. By contrast, other factors must play a dominant role in regulating net intestinal PO4 and Mg absorption.

Original languageEnglish (US)
Pages (from-to)2052-2060
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume32
Issue number10
StatePublished - 1979
Externally publishedYes

Fingerprint

ergocalciferol
Ergocalciferols
calcium phosphates
magnesium
Intestinal Absorption
vitamin D
kidneys
hormones
Vitamin D
intestinal absorption
Hormones
Kidney
ingestion
calcium magnesium phosphate
Eating
diet
Diet

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Plasma 1,25-(OH)2-vitamin D concentrations and net intestinal calcium, phosphate, and magnesium absorption in humans. / Wilz, D. R.; Gray, R. W.; Dominguez, Jesus; Lemann, J.

In: American Journal of Clinical Nutrition, Vol. 32, No. 10, 1979, p. 2052-2060.

Research output: Contribution to journalArticle

@article{edeeface81ee43709c5415e3ba009a7e,
title = "Plasma 1,25-(OH)2-vitamin D concentrations and net intestinal calcium, phosphate, and magnesium absorption in humans",
abstract = "The relationship was established between plasma concentrations of the renal hormone 1,25-(OH)2-vitamin D and net intestinal absorption of Ca, PO4, and Mg in vitamin D-replete patients eating similar diets, who had undetectable, normal or elevated plasma 1,25-(OH)2-D levels. Net intestinal CA absorption was positively correlated to plasma 1,25-(OH)2-D concentrations: percentage dietary CA absorbed = 10 + 0.17 x plasma total 1,25-(OH)2-D, pmole/liter, r = +0.58; P <0.001. By contrast, there was no significant correlation between PO4 or MG absorption and plasma 1,25-(OH)2-D concentrations. Moreover, significant quantities of PO4 and Mg were absorbed in the absence of detectable plasma 1,25-(OH)2-D. It is concluded that net intestinal Ca absorption is critically dependent upon the availability of the renal hormone 1,25-(OH)2-D in vitamin D-replete humans when dietary CA intake is normal. By contrast, other factors must play a dominant role in regulating net intestinal PO4 and Mg absorption.",
author = "Wilz, {D. R.} and Gray, {R. W.} and Jesus Dominguez and J. Lemann",
year = "1979",
language = "English (US)",
volume = "32",
pages = "2052--2060",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "10",

}

TY - JOUR

T1 - Plasma 1,25-(OH)2-vitamin D concentrations and net intestinal calcium, phosphate, and magnesium absorption in humans

AU - Wilz, D. R.

AU - Gray, R. W.

AU - Dominguez, Jesus

AU - Lemann, J.

PY - 1979

Y1 - 1979

N2 - The relationship was established between plasma concentrations of the renal hormone 1,25-(OH)2-vitamin D and net intestinal absorption of Ca, PO4, and Mg in vitamin D-replete patients eating similar diets, who had undetectable, normal or elevated plasma 1,25-(OH)2-D levels. Net intestinal CA absorption was positively correlated to plasma 1,25-(OH)2-D concentrations: percentage dietary CA absorbed = 10 + 0.17 x plasma total 1,25-(OH)2-D, pmole/liter, r = +0.58; P <0.001. By contrast, there was no significant correlation between PO4 or MG absorption and plasma 1,25-(OH)2-D concentrations. Moreover, significant quantities of PO4 and Mg were absorbed in the absence of detectable plasma 1,25-(OH)2-D. It is concluded that net intestinal Ca absorption is critically dependent upon the availability of the renal hormone 1,25-(OH)2-D in vitamin D-replete humans when dietary CA intake is normal. By contrast, other factors must play a dominant role in regulating net intestinal PO4 and Mg absorption.

AB - The relationship was established between plasma concentrations of the renal hormone 1,25-(OH)2-vitamin D and net intestinal absorption of Ca, PO4, and Mg in vitamin D-replete patients eating similar diets, who had undetectable, normal or elevated plasma 1,25-(OH)2-D levels. Net intestinal CA absorption was positively correlated to plasma 1,25-(OH)2-D concentrations: percentage dietary CA absorbed = 10 + 0.17 x plasma total 1,25-(OH)2-D, pmole/liter, r = +0.58; P <0.001. By contrast, there was no significant correlation between PO4 or MG absorption and plasma 1,25-(OH)2-D concentrations. Moreover, significant quantities of PO4 and Mg were absorbed in the absence of detectable plasma 1,25-(OH)2-D. It is concluded that net intestinal Ca absorption is critically dependent upon the availability of the renal hormone 1,25-(OH)2-D in vitamin D-replete humans when dietary CA intake is normal. By contrast, other factors must play a dominant role in regulating net intestinal PO4 and Mg absorption.

UR - http://www.scopus.com/inward/record.url?scp=0018734120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018734120&partnerID=8YFLogxK

M3 - Article

C2 - 484524

AN - SCOPUS:0018734120

VL - 32

SP - 2052

EP - 2060

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 10

ER -