Plasma 1,25-(OH)2-vitamin D concentrations and net intestinal calcium, phosphate, and magnesium absorption in humans

D. R. Wilz, R. W. Gray, J. H. Dominguez, J. Lemann

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

The relationship was established between plasma concentrations of the renal hormone 1,25-(OH)2-vitamin D and net intestinal absorption of Ca, PO4, and Mg in vitamin D-replete patients eating similar diets, who had undetectable, normal or elevated plasma 1,25-(OH)2-D levels. Net intestinal CA absorption was positively correlated to plasma 1,25-(OH)2-D concentrations: percentage dietary CA absorbed = 10 + 0.17 x plasma total 1,25-(OH)2-D, pmole/liter, r = +0.58; P < 0.001. By contrast, there was no significant correlation between PO4 or MG absorption and plasma 1,25-(OH)2-D concentrations. Moreover, significant quantities of PO4 and Mg were absorbed in the absence of detectable plasma 1,25-(OH)2-D. It is concluded that net intestinal Ca absorption is critically dependent upon the availability of the renal hormone 1,25-(OH)2-D in vitamin D-replete humans when dietary CA intake is normal. By contrast, other factors must play a dominant role in regulating net intestinal PO4 and Mg absorption.

Original languageEnglish (US)
Pages (from-to)2052-2060
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume32
Issue number10
DOIs
StatePublished - 1979

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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