Plasma Biomarkers in Graft-versus-Host Disease: A New Era?

Sophie Paczesny, John E. Levine, Thomas M. Braun, James L.M. Ferrara

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Acute graft versus host disease (GVHD) remains a major complication of allogeneic hematopoietic cell transplantation (HCT). The diagnosis of acute GVHD is based on strictly clinical criteria and its severity also determined by these criteria. Currently, there is no validated diagnostic blood test for acute GVHD. This review will summarize proteomics approaches to identify biomarkers for GVHD in the plasma with diagnostic, prognostic and predictive value. If successful, these studies could establish a novel biomarker panel that will contribute important information including long term survival, and that may eventually facilitate therapeutic decisions for allogeneic HCT patients.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume15
Issue number1 SUPPL.
DOIs
StatePublished - Jan 2009

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Keywords

  • Graft versus host disease
  • biomarkers panel
  • plasma biomarker
  • proteomics

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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