Plasma biomarkers of lower gastrointestinal and liver acute GVHD

Andrew C. Harris, James L.M. Ferrara, Thomas M. Braun, Ernst Holler, Takanori Teshima, John E. Levine, Sung W. Choi, Karin Landfried, Koichi Akashi, Mark Vander Lugt, Daniel R. Couriel, Pavan Reddy, Sophie Paczesny

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

The lower gastrointestinal tract (LGI) and liver are the GVHD target organs most associated with treatment failure and nonrelapse mortality. We recently identified regenerating islet-derived 3-α (REG3α) as a plasma biomarker of LGI GVHD. We compared REG3α with 2 previously reported GI and liver GVHD diagnostic biomarkers, hepatocyte growth factor (HGF) and cytokeratin fragment 18, in 954 hematopoietic cell transplantation patients. All 3 biomarkers were significantly elevated in LGI GVHD compared with non-GVHD diarrhea; REG3α discerned LGI GVHD from non-GVHD diarrhea better than HGF and cytokeratin fragment 18. Although all 3 biomarkers predicted nonresponse to therapy at day 28 in LGI GVHD patients, only REG3α and HGF concentrations predicted 1-year nonrelapse mortality (P = .01 and P = .02, respectively). Liver GVHD without GI involvement at GVHD onset and non-GVHD liver complications were uncommon; all 3 biomarkers were elevated in liver GVHD, but did not distinguish GVHD from other causes of hyperbilirubinemia.

Original languageEnglish (US)
Pages (from-to)2960-2963
Number of pages4
JournalBlood
Volume119
Issue number12
DOIs
StatePublished - Mar 22 2012

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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