Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients

Kumar Sharma, Robert V. Considine, Beckie Michael, Stephen R. Dunn, Lawrence S. Weisberg, Brenda R.C. Kurnik, Peter B. Kurnik, John O'Connor, Madhur Sinha, José F. Caro

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Abstract

Leptin, the gene product of the ob gene, is important in the control of appetite in rodents and may have an important role in humans. The clearance of leptin from the circulation is unknown. As the leptin receptor is present in the kidney, we evaluated the role of the kidney in removing circulating leptin in humans. We measured leptin in aortic and renal vein plasma in 8 patients with intact renal function and 6 patients with impaired renal function who were undergoing elective cardiac catheterization. Renal blood flow was measured in all patients to calculate net mass balance across the kidney. In patients with intact renal function there is net renal uptake of 12% of circulating leptin, whereas in patients with renal insufficiency there is no renal uptake of leptin. In a separate cohort of 36 patients with end-stage renal failure on hemodialysis, peripheral leptin levels factored for body mass index was increased by > fourfold as compared to a group of healthy controls (N = 338). In addition, plasma leptin is not cleared by hemodialysis with a modified cellulose membrane. Additional studies are required to evaluate the role of leptin in mediating the anorexia of uremia.

Original languageEnglish (US)
Pages (from-to)1980-1985
Number of pages6
JournalKidney international
Volume51
Issue number6
DOIs
StatePublished - Jan 1 1997

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Leptin
Renal Dialysis
Kidney
Leptin Receptors
Renal Veins
Renal Circulation
Uremia
Anorexia
Appetite
Cardiac Catheterization
Cellulose
Chronic Kidney Failure
Renal Insufficiency
Rodentia
Body Mass Index
Control Groups
Membranes

ASJC Scopus subject areas

  • Nephrology

Cite this

Sharma, K., Considine, R. V., Michael, B., Dunn, S. R., Weisberg, L. S., Kurnik, B. R. C., ... Caro, J. F. (1997). Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients. Kidney international, 51(6), 1980-1985. https://doi.org/10.1038/ki.1997.269

Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients. / Sharma, Kumar; Considine, Robert V.; Michael, Beckie; Dunn, Stephen R.; Weisberg, Lawrence S.; Kurnik, Brenda R.C.; Kurnik, Peter B.; O'Connor, John; Sinha, Madhur; Caro, José F.

In: Kidney international, Vol. 51, No. 6, 01.01.1997, p. 1980-1985.

Research output: Contribution to journalArticle

Sharma, K, Considine, RV, Michael, B, Dunn, SR, Weisberg, LS, Kurnik, BRC, Kurnik, PB, O'Connor, J, Sinha, M & Caro, JF 1997, 'Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients', Kidney international, vol. 51, no. 6, pp. 1980-1985. https://doi.org/10.1038/ki.1997.269
Sharma, Kumar ; Considine, Robert V. ; Michael, Beckie ; Dunn, Stephen R. ; Weisberg, Lawrence S. ; Kurnik, Brenda R.C. ; Kurnik, Peter B. ; O'Connor, John ; Sinha, Madhur ; Caro, José F. / Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients. In: Kidney international. 1997 ; Vol. 51, No. 6. pp. 1980-1985.
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