Plasma MHPG in Rapid Cyclers and Healthy Twins

David C. Jimerson, John Nurnberger, Robert M. Post, Elliot S. Gershon, Irwin J. Kopin

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

We measured plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) in 13 pairs of healthy drug-free monozygotic twins. High concordance for both free and conjugated MHPG suggests that plasma levels of the metabolite may reflect a heritable biological trait. In two drug-free rapidly cycling patients studied longitudinally, plasma MHPG levels reflected alterations in psychiatric state; they were significantly higher during mania than during depression. Although largely reflecting peripheral sources, plasma MHPG level as a global index of noradrenergic function may complement urinary MHPG excretion as a probe for diagnostic subgroups or pharmacologic responsiveness in psychiatric research.

Original languageEnglish (US)
Pages (from-to)1287-1290
Number of pages4
JournalArchives of General Psychiatry
Volume38
Issue number11
DOIs
StatePublished - 1981
Externally publishedYes

Fingerprint

Psychiatry
Complement C3
Monozygotic Twins
Bipolar Disorder
Pharmaceutical Preparations
4-hydroxyphenethylene glycol
Plasma
Depression
Research
Drugs
Cycling
Concordance
Alteration
Diagnostics
Responsiveness
Mania

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Plasma MHPG in Rapid Cyclers and Healthy Twins. / Jimerson, David C.; Nurnberger, John; Post, Robert M.; Gershon, Elliot S.; Kopin, Irwin J.

In: Archives of General Psychiatry, Vol. 38, No. 11, 1981, p. 1287-1290.

Research output: Contribution to journalArticle

Jimerson, David C. ; Nurnberger, John ; Post, Robert M. ; Gershon, Elliot S. ; Kopin, Irwin J. / Plasma MHPG in Rapid Cyclers and Healthy Twins. In: Archives of General Psychiatry. 1981 ; Vol. 38, No. 11. pp. 1287-1290.
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