Plasma norepinephrine in chronic schizophrenia

Alan Breier, Owen M. Wolkowitz, Alec Roy, William Z. Potter, David Pickar

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Several lines of evidence indicate altered noradrenergic function in schizophrenia. The authors examined resting, standing, and change (standing minus resting) in plasma norepinephrine levels in 14 drug-free patients with chronic schizophrenia or schizoaffective disorder and in 33 age- and sex-matched healthy volunteers. Schizophrenic patients had significantly higher resting and standing plasma norepinephrine levels and significantly greater change. Resting and standing levels were significantly related to positive and negative symptoms. There was a significant positive correlation between resting plasma and CSF norepinephrine levels and a significant negative correlation between CSF homovanillic acid and resting, standing, and change in plasma norepinephrine levels.

Original languageEnglish (US)
Pages (from-to)1467-1470
Number of pages4
JournalAmerican Journal of Psychiatry
Volume147
Issue number11
StatePublished - 1990
Externally publishedYes

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Schizophrenia
Norepinephrine
Homovanillic Acid
Psychotic Disorders
Healthy Volunteers
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Breier, A., Wolkowitz, O. M., Roy, A., Potter, W. Z., & Pickar, D. (1990). Plasma norepinephrine in chronic schizophrenia. American Journal of Psychiatry, 147(11), 1467-1470.

Plasma norepinephrine in chronic schizophrenia. / Breier, Alan; Wolkowitz, Owen M.; Roy, Alec; Potter, William Z.; Pickar, David.

In: American Journal of Psychiatry, Vol. 147, No. 11, 1990, p. 1467-1470.

Research output: Contribution to journalArticle

Breier, A, Wolkowitz, OM, Roy, A, Potter, WZ & Pickar, D 1990, 'Plasma norepinephrine in chronic schizophrenia', American Journal of Psychiatry, vol. 147, no. 11, pp. 1467-1470.
Breier A, Wolkowitz OM, Roy A, Potter WZ, Pickar D. Plasma norepinephrine in chronic schizophrenia. American Journal of Psychiatry. 1990;147(11):1467-1470.
Breier, Alan ; Wolkowitz, Owen M. ; Roy, Alec ; Potter, William Z. ; Pickar, David. / Plasma norepinephrine in chronic schizophrenia. In: American Journal of Psychiatry. 1990 ; Vol. 147, No. 11. pp. 1467-1470.
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