Plasma viral loads during early HIV-1 infection are similar in subtype C-and non-subtype C-infected African seroconverters

Mary S. Campbell, Erin M. Kahle, Connie Celum, Jairam R. Lingappa, Saidi Kapiga, Andrew Mujugira, Nelly R. Mugo, Kenneth H. Fife, James I. Mullins, Jared M. Baeten

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Recent data suggest that infection with human immunodeficiency virus type 1 (HIV-1) subtype C results in prolonged high-level viremia (>5 log 10 copies/mL) during early infection. We examined the relationship between HIV-1 subtype and plasma viremia among 153 African seroconverters. Mean setpoint viral loads were similar for C and non-C subtypes: 4.36 vs 4.42 log10 copies/mL (P =. 61). The proportion of subtype C-infected participants with viral loads >5 log10 copies/mL was not greater than the proportion for those with non-C infection. Our data do not support the hypothesis that higher early viral load accounts for the rapid spread of HIV-1 subtype C in southern Africa.

Original languageEnglish (US)
Pages (from-to)1166-1170
Number of pages5
JournalJournal of Infectious Diseases
Volume207
Issue number7
DOIs
StatePublished - Apr 1 2013
Externally publishedYes

Keywords

  • Africa
  • early infection
  • group M subtype
  • HIV-1
  • plasma viral load

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

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    Campbell, M. S., Kahle, E. M., Celum, C., Lingappa, J. R., Kapiga, S., Mujugira, A., Mugo, N. R., Fife, K. H., Mullins, J. I., & Baeten, J. M. (2013). Plasma viral loads during early HIV-1 infection are similar in subtype C-and non-subtype C-infected African seroconverters. Journal of Infectious Diseases, 207(7), 1166-1170. https://doi.org/10.1093/infdis/jit015