Urokinaznyi aktivator plazminogena: mekhanizmy uchastiia v remodelirovanii sosudov i angiogeneze, genno-terapevticheskie podkhody k revaskuliariztsii.

Translated title of the contribution: Plasminogen activator of urokinase-type: mechanisms of involvement in vessel remodeling and angiogenesis, gene therapy approaches to ischemia

E. V. Parfenova, V. V. Plekhanova, V. V. Stepanova, M. I. Men'shikov, Z. I. Tsokaleva, K. A. Talitskiǐ, T. M. Rakhmat-zade, Dmitry Traktuev, N. A. Torosian, N. I. Rogunova, E. I. Ratner, V. A. Tkachuk

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The review summarizes data obtained by the authors and other laboratories concerning the role of urokinase plasminogen activator in vessel remodeling and angiogenesis. The data have shown that urokinase is involved in unfavorable vascular remodeling during the development of restenosis, atherosclerosis and also in the regulation of angiogenesis. Urokinase is a promising target for therapeutic interventions aimed at restenosis prevention. Urokinase gene therapy may be a perspective strategy for the treatment of tissue ischemia.

Original languageUndefined/Unknown
Pages (from-to)547-568
Number of pages22
JournalRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk
Volume90
Issue number5
StatePublished - May 2004
Externally publishedYes

Fingerprint

Urokinase-Type Plasminogen Activator
Genetic Therapy
Ischemia
Plasminogen Activators
Atherosclerosis
Therapeutics

ASJC Scopus subject areas

  • Physiology

Cite this

Parfenova, E. V., Plekhanova, V. V., Stepanova, V. V., Men'shikov, M. I., Tsokaleva, Z. I., Talitskiǐ, K. A., ... Tkachuk, V. A. (2004). Urokinaznyi aktivator plazminogena: mekhanizmy uchastiia v remodelirovanii sosudov i angiogeneze, genno-terapevticheskie podkhody k revaskuliariztsii. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk, 90(5), 547-568.

Urokinaznyi aktivator plazminogena : mekhanizmy uchastiia v remodelirovanii sosudov i angiogeneze, genno-terapevticheskie podkhody k revaskuliariztsii. / Parfenova, E. V.; Plekhanova, V. V.; Stepanova, V. V.; Men'shikov, M. I.; Tsokaleva, Z. I.; Talitskiǐ, K. A.; Rakhmat-zade, T. M.; Traktuev, Dmitry; Torosian, N. A.; Rogunova, N. I.; Ratner, E. I.; Tkachuk, V. A.

In: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk, Vol. 90, No. 5, 05.2004, p. 547-568.

Research output: Contribution to journalArticle

Parfenova, EV, Plekhanova, VV, Stepanova, VV, Men'shikov, MI, Tsokaleva, ZI, Talitskiǐ, KA, Rakhmat-zade, TM, Traktuev, D, Torosian, NA, Rogunova, NI, Ratner, EI & Tkachuk, VA 2004, 'Urokinaznyi aktivator plazminogena: mekhanizmy uchastiia v remodelirovanii sosudov i angiogeneze, genno-terapevticheskie podkhody k revaskuliariztsii.', Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk, vol. 90, no. 5, pp. 547-568.
Parfenova, E. V. ; Plekhanova, V. V. ; Stepanova, V. V. ; Men'shikov, M. I. ; Tsokaleva, Z. I. ; Talitskiǐ, K. A. ; Rakhmat-zade, T. M. ; Traktuev, Dmitry ; Torosian, N. A. ; Rogunova, N. I. ; Ratner, E. I. ; Tkachuk, V. A. / Urokinaznyi aktivator plazminogena : mekhanizmy uchastiia v remodelirovanii sosudov i angiogeneze, genno-terapevticheskie podkhody k revaskuliariztsii. In: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk. 2004 ; Vol. 90, No. 5. pp. 547-568.
@article{829c84c7921540dbbe084babc43ce372,
title = "Urokinaznyi aktivator plazminogena: mekhanizmy uchastiia v remodelirovanii sosudov i angiogeneze, genno-terapevticheskie podkhody k revaskuliariztsii.",
abstract = "The review summarizes data obtained by the authors and other laboratories concerning the role of urokinase plasminogen activator in vessel remodeling and angiogenesis. The data have shown that urokinase is involved in unfavorable vascular remodeling during the development of restenosis, atherosclerosis and also in the regulation of angiogenesis. Urokinase is a promising target for therapeutic interventions aimed at restenosis prevention. Urokinase gene therapy may be a perspective strategy for the treatment of tissue ischemia.",
author = "Parfenova, {E. V.} and Plekhanova, {V. V.} and Stepanova, {V. V.} and Men'shikov, {M. I.} and Tsokaleva, {Z. I.} and Talitskiǐ, {K. A.} and Rakhmat-zade, {T. M.} and Dmitry Traktuev and Torosian, {N. A.} and Rogunova, {N. I.} and Ratner, {E. I.} and Tkachuk, {V. A.}",
year = "2004",
month = "5",
language = "Undefined/Unknown",
volume = "90",
pages = "547--568",
journal = "Fiziologicheskii Zhurnal Imeni I.M. Sechenova",
issn = "0869-8139",
publisher = "Nauka Publishers",
number = "5",

}

TY - JOUR

T1 - Urokinaznyi aktivator plazminogena

T2 - mekhanizmy uchastiia v remodelirovanii sosudov i angiogeneze, genno-terapevticheskie podkhody k revaskuliariztsii.

AU - Parfenova, E. V.

AU - Plekhanova, V. V.

AU - Stepanova, V. V.

AU - Men'shikov, M. I.

AU - Tsokaleva, Z. I.

AU - Talitskiǐ, K. A.

AU - Rakhmat-zade, T. M.

AU - Traktuev, Dmitry

AU - Torosian, N. A.

AU - Rogunova, N. I.

AU - Ratner, E. I.

AU - Tkachuk, V. A.

PY - 2004/5

Y1 - 2004/5

N2 - The review summarizes data obtained by the authors and other laboratories concerning the role of urokinase plasminogen activator in vessel remodeling and angiogenesis. The data have shown that urokinase is involved in unfavorable vascular remodeling during the development of restenosis, atherosclerosis and also in the regulation of angiogenesis. Urokinase is a promising target for therapeutic interventions aimed at restenosis prevention. Urokinase gene therapy may be a perspective strategy for the treatment of tissue ischemia.

AB - The review summarizes data obtained by the authors and other laboratories concerning the role of urokinase plasminogen activator in vessel remodeling and angiogenesis. The data have shown that urokinase is involved in unfavorable vascular remodeling during the development of restenosis, atherosclerosis and also in the regulation of angiogenesis. Urokinase is a promising target for therapeutic interventions aimed at restenosis prevention. Urokinase gene therapy may be a perspective strategy for the treatment of tissue ischemia.

UR - http://www.scopus.com/inward/record.url?scp=28744448186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28744448186&partnerID=8YFLogxK

M3 - Article

C2 - 15341081

AN - SCOPUS:28744448186

VL - 90

SP - 547

EP - 568

JO - Fiziologicheskii Zhurnal Imeni I.M. Sechenova

JF - Fiziologicheskii Zhurnal Imeni I.M. Sechenova

SN - 0869-8139

IS - 5

ER -