Urokinaznyi aktivator plazminogena: mekhanizmy uchastiia v remodelirovanii sosudov i angiogeneze, genno-terapevticheskie podkhody k revaskuliariztsii.

Translated title of the contribution: Plasminogen activator of urokinase-type: mechanisms of involvement in vessel remodeling and angiogenesis, gene therapy approaches to ischemia

E. V. Parfenova, V. V. Plekhanova, V. V. Stepanova, M. I. Men'shikov, Z. I. Tsokaleva, K. A. Talitskiǐ, T. M. Rakhmat-zade, D. O. Traktuev, N. A. Torosian, N. I. Rogunova, E. I. Ratner, V. A. Tkachuk

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

The review summarizes data obtained by the authors and other laboratories concerning the role of urokinase plasminogen activator in vessel remodeling and angiogenesis. The data have shown that urokinase is involved in unfavorable vascular remodeling during the development of restenosis, atherosclerosis and also in the regulation of angiogenesis. Urokinase is a promising target for therapeutic interventions aimed at restenosis prevention. Urokinase gene therapy may be a perspective strategy for the treatment of tissue ischemia.

Original languageRussian
Pages (from-to)547-568
Number of pages22
JournalRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk
Volume90
Issue number5
StatePublished - May 1 2004

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Parfenova, E. V., Plekhanova, V. V., Stepanova, V. V., Men'shikov, M. I., Tsokaleva, Z. I., Talitskiǐ, K. A., Rakhmat-zade, T. M., Traktuev, D. O., Torosian, N. A., Rogunova, N. I., Ratner, E. I., & Tkachuk, V. A. (2004). Urokinaznyi aktivator plazminogena: mekhanizmy uchastiia v remodelirovanii sosudov i angiogeneze, genno-terapevticheskie podkhody k revaskuliariztsii. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk, 90(5), 547-568.