Platelet-Activating Factor as an Effector for Environmental Stressors

Research output: Contribution to journalArticle

Abstract

Environmental stressors exert a profound effect on humans. Many environmental stressors have in common the ability to induce reactive oxygen species. The goal of this chapter is to present evidence that the potent lipid mediator platelet-activating factor (PAF) is involved in the effects of many stressors ranging from cigarette smoke to ultraviolet B radiation. These environmental stressors can generate PAF enzymatically as well as PAF-like lipids produced by free radical-mediated attack of glycerophosphocholines. Inasmuch as PAF exerts both acute inflammation and delayed immunosuppressive effects, involvement of the PAF system can provide an explanation for many consequences of environmental stressor exposures.

Original languageEnglish (US)
Pages (from-to)185-203
Number of pages19
JournalHandbook of experimental pharmacology
Volume259
DOIs
StatePublished - Jan 1 2020
Externally publishedYes

Keywords

  • Immunosuppression
  • Microvesicle particles
  • Platelet-activating factor
  • Reactive oxygen species
  • Skin
  • Ultraviolet radiation

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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