Platelet-activating factor does not mediate uvb-induced local immune suppression

Ravi P. Sahu, Yongxue Yao, Raymond Konger, Jeffrey Travers

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The lipid mediator Platelet-activating factor (PAF) and oxidized glycerophosphocholine PAF agonists produced by UVB have been demonstrated to play a pivotal role in UVB-mediated systemic immunosuppression. Importantly, employing the ability of distant UVB irradiation to inhibit contact hypersensitivity (CHS) responses to the chemical antigen dinitrofluorobenzene (DNFB) to an area of unirradiated murine skin, we and others have demonstrated that UVB-mediated systemic immunosuppression was only observed in PAF-R expressing wild type (WT) mice and not in PAF-R-knockout (Pafr-/-) mice. As it is not known if PAF is involved in UVB-mediated local immunosuppression, these studies compared local UVB on CHS responses in WT versus Pafr-/- mice. We demonstrate that the application of DNFB onto UVB-exposed (locally) area of mouse skin resulted in a similar significant inhibition of subsequent CHS responses in both WT and Pafr-/- mice compared to sham-irradiated control mice. Furthermore, the expression of langerin, a marker for the presence of Langerhans cells was substantially reduced equally in the epidermal ears of UVB-irradiated WT and Pafr-/- mice compared to their respective sham control groups. These findings indicate that the PAF-R is not involved UVB-induced local immunosuppression.

Original languageEnglish
Pages (from-to)490-493
Number of pages4
JournalPhotochemistry and Photobiology
Volume88
Issue number2
DOIs
StatePublished - Mar 2012

Fingerprint

Platelet Activating Factor
immunosuppression
knockout mice
platelets
retarding
Knockout Mice
Immunosuppression
Contact Dermatitis
Dinitrofluorobenzene
mice
Skin
Langerhans Cells
ear
antigens
markers
Ear
lipids
Irradiation
Lipids
Antigens

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Biochemistry
  • Medicine(all)

Cite this

Platelet-activating factor does not mediate uvb-induced local immune suppression. / Sahu, Ravi P.; Yao, Yongxue; Konger, Raymond; Travers, Jeffrey.

In: Photochemistry and Photobiology, Vol. 88, No. 2, 03.2012, p. 490-493.

Research output: Contribution to journalArticle

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