Platelet GABA-transaminase in affective illness

Wade H. Berrettini, Brinda Umberkoman-Wiita, John Nurnberger, Wolfgang H. Vogel, Elliot S. Gershon, Robert M. Post

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Platelet γ-aminobutyric acid (GABA)-transaminase was measured in 18 bipolar patients, 59 normal volunteers, and 9 pairs of monozygotic twins. A significantly lower mean activity was observed in the bipolar group, although lower female bipolar values may account for most of the difference. Enzyme activity was correlated in monozygotic twins, suggesting genetic influences on enzyme activity. Values obtained in the postprandial state were significantly lower than values in the fasting state. These data are discussed in light of other evidence of altered GABA metabolism in affective illness.

Original languageEnglish (US)
Pages (from-to)255-260
Number of pages6
JournalPsychiatry Research
Volume7
Issue number2
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

4-Aminobutyrate Transaminase
Monozygotic Twins
Blood Platelets
Aminobutyrates
Enzymes
gamma-Aminobutyric Acid
Fasting
Healthy Volunteers

Keywords

  • affective disorders
  • GABA
  • GABA-transaminase
  • genetics
  • monozygotic twins

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Berrettini, W. H., Umberkoman-Wiita, B., Nurnberger, J., Vogel, W. H., Gershon, E. S., & Post, R. M. (1982). Platelet GABA-transaminase in affective illness. Psychiatry Research, 7(2), 255-260. https://doi.org/10.1016/0165-1781(92)90098-N

Platelet GABA-transaminase in affective illness. / Berrettini, Wade H.; Umberkoman-Wiita, Brinda; Nurnberger, John; Vogel, Wolfgang H.; Gershon, Elliot S.; Post, Robert M.

In: Psychiatry Research, Vol. 7, No. 2, 1982, p. 255-260.

Research output: Contribution to journalArticle

Berrettini, WH, Umberkoman-Wiita, B, Nurnberger, J, Vogel, WH, Gershon, ES & Post, RM 1982, 'Platelet GABA-transaminase in affective illness', Psychiatry Research, vol. 7, no. 2, pp. 255-260. https://doi.org/10.1016/0165-1781(92)90098-N
Berrettini WH, Umberkoman-Wiita B, Nurnberger J, Vogel WH, Gershon ES, Post RM. Platelet GABA-transaminase in affective illness. Psychiatry Research. 1982;7(2):255-260. https://doi.org/10.1016/0165-1781(92)90098-N
Berrettini, Wade H. ; Umberkoman-Wiita, Brinda ; Nurnberger, John ; Vogel, Wolfgang H. ; Gershon, Elliot S. ; Post, Robert M. / Platelet GABA-transaminase in affective illness. In: Psychiatry Research. 1982 ; Vol. 7, No. 2. pp. 255-260.
@article{67558045190b44c8b028e44592f71a7a,
title = "Platelet GABA-transaminase in affective illness",
abstract = "Platelet γ-aminobutyric acid (GABA)-transaminase was measured in 18 bipolar patients, 59 normal volunteers, and 9 pairs of monozygotic twins. A significantly lower mean activity was observed in the bipolar group, although lower female bipolar values may account for most of the difference. Enzyme activity was correlated in monozygotic twins, suggesting genetic influences on enzyme activity. Values obtained in the postprandial state were significantly lower than values in the fasting state. These data are discussed in light of other evidence of altered GABA metabolism in affective illness.",
keywords = "affective disorders, GABA, GABA-transaminase, genetics, monozygotic twins",
author = "Berrettini, {Wade H.} and Brinda Umberkoman-Wiita and John Nurnberger and Vogel, {Wolfgang H.} and Gershon, {Elliot S.} and Post, {Robert M.}",
year = "1982",
doi = "10.1016/0165-1781(92)90098-N",
language = "English (US)",
volume = "7",
pages = "255--260",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Platelet GABA-transaminase in affective illness

AU - Berrettini, Wade H.

AU - Umberkoman-Wiita, Brinda

AU - Nurnberger, John

AU - Vogel, Wolfgang H.

AU - Gershon, Elliot S.

AU - Post, Robert M.

PY - 1982

Y1 - 1982

N2 - Platelet γ-aminobutyric acid (GABA)-transaminase was measured in 18 bipolar patients, 59 normal volunteers, and 9 pairs of monozygotic twins. A significantly lower mean activity was observed in the bipolar group, although lower female bipolar values may account for most of the difference. Enzyme activity was correlated in monozygotic twins, suggesting genetic influences on enzyme activity. Values obtained in the postprandial state were significantly lower than values in the fasting state. These data are discussed in light of other evidence of altered GABA metabolism in affective illness.

AB - Platelet γ-aminobutyric acid (GABA)-transaminase was measured in 18 bipolar patients, 59 normal volunteers, and 9 pairs of monozygotic twins. A significantly lower mean activity was observed in the bipolar group, although lower female bipolar values may account for most of the difference. Enzyme activity was correlated in monozygotic twins, suggesting genetic influences on enzyme activity. Values obtained in the postprandial state were significantly lower than values in the fasting state. These data are discussed in light of other evidence of altered GABA metabolism in affective illness.

KW - affective disorders

KW - GABA

KW - GABA-transaminase

KW - genetics

KW - monozygotic twins

UR - http://www.scopus.com/inward/record.url?scp=0020447710&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020447710&partnerID=8YFLogxK

U2 - 10.1016/0165-1781(92)90098-N

DO - 10.1016/0165-1781(92)90098-N

M3 - Article

C2 - 6959173

AN - SCOPUS:0020447710

VL - 7

SP - 255

EP - 260

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 2

ER -