Platelet GABA-transaminase in affective illness

Wade H. Berrettini, Brinda Umberkoman-Wiita, John I. Nurnberger, Wolfgang H. Vogel, Elliot S. Gershon, Robert M. Post

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Platelet γ-aminobutyric acid (GABA)-transaminase was measured in 18 bipolar patients, 59 normal volunteers, and 9 pairs of monozygotic twins. A significantly lower mean activity was observed in the bipolar group, although lower female bipolar values may account for most of the difference. Enzyme activity was correlated in monozygotic twins, suggesting genetic influences on enzyme activity. Values obtained in the postprandial state were significantly lower than values in the fasting state. These data are discussed in light of other evidence of altered GABA metabolism in affective illness.

Original languageEnglish (US)
Pages (from-to)255-260
Number of pages6
JournalPsychiatry Research
Volume7
Issue number2
DOIs
StatePublished - Oct 1982
Externally publishedYes

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Keywords

  • GABA
  • GABA-transaminase
  • affective disorders
  • genetics
  • monozygotic twins

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Berrettini, W. H., Umberkoman-Wiita, B., Nurnberger, J. I., Vogel, W. H., Gershon, E. S., & Post, R. M. (1982). Platelet GABA-transaminase in affective illness. Psychiatry Research, 7(2), 255-260. https://doi.org/10.1016/0165-1781(92)90098-N