Platelet 3H-imipramine binding in euthymic bipolar patients

Wade H. Berrettini, John I. Nurnberger, Robert M. Post, Elliot S. Gershon

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Several recent studies have reported decreased maximal binding (βmax) of 3H-imipramine to platelets obtained from depressed patients. 3H-imipramine binding was measured in 12 medication-free euthymic bipolar patients and 12 normal volunteers to determine whether the decreased βmax persisted in the euthymic state. No differences between these two groups were found in βmax or binding affinity (Kd). This suggests that 3H-imipramine binding to platelets is not a state-independent marker for affective illness.

Original languageEnglish (US)
Pages (from-to)215-219
Number of pages5
JournalPsychiatry Research
Issue number2
StatePublished - Oct 1982
Externally publishedYes


  • Euthymic bipolars
  • H-imipramine binding
  • platelet

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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