Pleiotropic effects of prostaglandin E 2 in hematopoiesis; Prostaglandin E 2 and other eicosanoids regulate hematopoietic stem and progenitor cell function

Louis Pelus, Jonathan Hoggatt

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Eicosanoids have been implicated in the physiological regulation of hematopoiesis with pleiotropic effects on hematopoietic stem cells and various classes of lineage restricted progenitor cells. Herein we review the effects of eicosanoids on hematopoiesis, focusing on new findings implicating prostaglandin E 2 in enhancing hematopoietic stem cell engraftment by enhancing stem cell homing, survival and self-renewal. We also describe a role for cannabinoids in hematopoiesis. Lastly, we discuss the yin and yang of various eicosanoids in modulating hematopoietic stem and progenitor cell functions and summarize potential strategies to take advantage of these effects for therapeutic benefit for hematopoietic stem cell transplantation.

Original languageEnglish
Pages (from-to)3-9
Number of pages7
JournalProstaglandins and Other Lipid Mediators
Volume96
Issue number1-4
DOIs
StatePublished - Nov 2011

Fingerprint

Eicosanoids
Hematopoiesis
Hematopoietic Stem Cells
Prostaglandins E
Stem cells
Stem Cells
Yin-Yang
Cannabinoids
Hematopoietic Stem Cell Transplantation
Therapeutic Uses
Cell Survival

Keywords

  • Eicosanoids
  • Hematopoietic stem cell homing
  • Hematopoietic stem cells
  • Stem cell engraftment
  • Transplantation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

Cite this

Pleiotropic effects of prostaglandin E 2 in hematopoiesis; Prostaglandin E 2 and other eicosanoids regulate hematopoietic stem and progenitor cell function. / Pelus, Louis M.; Hoggatt, Jonathan.

In: Prostaglandins and Other Lipid Mediators, Vol. 96, No. 1-4, 01.11.2011, p. 3-9.

Research output: Contribution to journalReview article

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