Pleiotropic effects of prostaglandin E 2 in hematopoiesis; Prostaglandin E 2 and other eicosanoids regulate hematopoietic stem and progenitor cell function

Louis M. Pelus, Jonathan Hoggatt

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Eicosanoids have been implicated in the physiological regulation of hematopoiesis with pleiotropic effects on hematopoietic stem cells and various classes of lineage restricted progenitor cells. Herein we review the effects of eicosanoids on hematopoiesis, focusing on new findings implicating prostaglandin E 2 in enhancing hematopoietic stem cell engraftment by enhancing stem cell homing, survival and self-renewal. We also describe a role for cannabinoids in hematopoiesis. Lastly, we discuss the yin and yang of various eicosanoids in modulating hematopoietic stem and progenitor cell functions and summarize potential strategies to take advantage of these effects for therapeutic benefit for hematopoietic stem cell transplantation.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalProstaglandins and Other Lipid Mediators
Volume96
Issue number1-4
DOIs
StatePublished - Nov 1 2011

Keywords

  • Eicosanoids
  • Hematopoietic stem cell homing
  • Hematopoietic stem cells
  • Stem cell engraftment
  • Transplantation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

Fingerprint Dive into the research topics of 'Pleiotropic effects of prostaglandin E <sub>2</sub> in hematopoiesis; Prostaglandin E <sub>2</sub> and other eicosanoids regulate hematopoietic stem and progenitor cell function'. Together they form a unique fingerprint.

  • Cite this