Pleomorphic adenoma (benign mixed tumor) of the breast. An immunohistochemical, flow cytometric, and ultrastructural study and review of the literature

W. A. Ballance, J. Y. Ro, A. K. El-Naggar, David Grignon, A. G. Ayala, M. G. Romsdahl

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Pleomorphic adenoma (or benign mixed tumor) of the breast is a rare benign neoplasm that might be misinterpreted both clinically and pathologically as a malignant tumor. The authors present an additional case of this unusual lesion studied by immunohistochemistry, electron microscopy, and flow cytometry. A 77-year-old white woman presented with a 2-cm, nontender, mobile, calcified, right subareolar mass suggestive of a fibroadenoma. Microscopically, the tumor resembled a pleomorphic adenoma occurring in salivary glands. Positive immunostaining for S-100 protein, cytokeratin, and muscle-specific actin, as well as the ultrastructural presence of intermediate filaments with dense bodies and intercellular junctions, supported the predominant myoepithelial cell differentiation within the tumor, whereas the epithelial cell component stained only with cytokeratin and contained formed lumina with surface microvilli. The DNA pattern was diploid. The patient is alive and well 14 months after surgery. The authors' findings confirm that plemorphic adenoma of the breast is a benign neoplasm in which myoepithelial cell proliferation plays a major role in tumorogenesis.

Original languageEnglish (US)
Pages (from-to)795-801
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume93
Issue number6
StatePublished - 1990
Externally publishedYes

Fingerprint

Pleomorphic Adenoma
Breast Neoplasms
Neoplasms
Keratins
Fibroadenoma
Intercellular Junctions
Intermediate Filaments
S100 Proteins
Cellular Structures
Microvilli
Salivary Glands
Diploidy
Adenoma
Actins
Cell Differentiation
Electron Microscopy
Flow Cytometry
Breast
Epithelial Cells
Immunohistochemistry

Keywords

  • Benign mixed tumor
  • Breast neoplasm
  • Pleomorphic adenoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Pleomorphic adenoma (benign mixed tumor) of the breast. An immunohistochemical, flow cytometric, and ultrastructural study and review of the literature. / Ballance, W. A.; Ro, J. Y.; El-Naggar, A. K.; Grignon, David; Ayala, A. G.; Romsdahl, M. G.

In: American Journal of Clinical Pathology, Vol. 93, No. 6, 1990, p. 795-801.

Research output: Contribution to journalArticle

@article{4c6bc01f7530458687a73e2b8338b996,
title = "Pleomorphic adenoma (benign mixed tumor) of the breast. An immunohistochemical, flow cytometric, and ultrastructural study and review of the literature",
abstract = "Pleomorphic adenoma (or benign mixed tumor) of the breast is a rare benign neoplasm that might be misinterpreted both clinically and pathologically as a malignant tumor. The authors present an additional case of this unusual lesion studied by immunohistochemistry, electron microscopy, and flow cytometry. A 77-year-old white woman presented with a 2-cm, nontender, mobile, calcified, right subareolar mass suggestive of a fibroadenoma. Microscopically, the tumor resembled a pleomorphic adenoma occurring in salivary glands. Positive immunostaining for S-100 protein, cytokeratin, and muscle-specific actin, as well as the ultrastructural presence of intermediate filaments with dense bodies and intercellular junctions, supported the predominant myoepithelial cell differentiation within the tumor, whereas the epithelial cell component stained only with cytokeratin and contained formed lumina with surface microvilli. The DNA pattern was diploid. The patient is alive and well 14 months after surgery. The authors' findings confirm that plemorphic adenoma of the breast is a benign neoplasm in which myoepithelial cell proliferation plays a major role in tumorogenesis.",
keywords = "Benign mixed tumor, Breast neoplasm, Pleomorphic adenoma",
author = "Ballance, {W. A.} and Ro, {J. Y.} and El-Naggar, {A. K.} and David Grignon and Ayala, {A. G.} and Romsdahl, {M. G.}",
year = "1990",
language = "English (US)",
volume = "93",
pages = "795--801",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "6",

}

TY - JOUR

T1 - Pleomorphic adenoma (benign mixed tumor) of the breast. An immunohistochemical, flow cytometric, and ultrastructural study and review of the literature

AU - Ballance, W. A.

AU - Ro, J. Y.

AU - El-Naggar, A. K.

AU - Grignon, David

AU - Ayala, A. G.

AU - Romsdahl, M. G.

PY - 1990

Y1 - 1990

N2 - Pleomorphic adenoma (or benign mixed tumor) of the breast is a rare benign neoplasm that might be misinterpreted both clinically and pathologically as a malignant tumor. The authors present an additional case of this unusual lesion studied by immunohistochemistry, electron microscopy, and flow cytometry. A 77-year-old white woman presented with a 2-cm, nontender, mobile, calcified, right subareolar mass suggestive of a fibroadenoma. Microscopically, the tumor resembled a pleomorphic adenoma occurring in salivary glands. Positive immunostaining for S-100 protein, cytokeratin, and muscle-specific actin, as well as the ultrastructural presence of intermediate filaments with dense bodies and intercellular junctions, supported the predominant myoepithelial cell differentiation within the tumor, whereas the epithelial cell component stained only with cytokeratin and contained formed lumina with surface microvilli. The DNA pattern was diploid. The patient is alive and well 14 months after surgery. The authors' findings confirm that plemorphic adenoma of the breast is a benign neoplasm in which myoepithelial cell proliferation plays a major role in tumorogenesis.

AB - Pleomorphic adenoma (or benign mixed tumor) of the breast is a rare benign neoplasm that might be misinterpreted both clinically and pathologically as a malignant tumor. The authors present an additional case of this unusual lesion studied by immunohistochemistry, electron microscopy, and flow cytometry. A 77-year-old white woman presented with a 2-cm, nontender, mobile, calcified, right subareolar mass suggestive of a fibroadenoma. Microscopically, the tumor resembled a pleomorphic adenoma occurring in salivary glands. Positive immunostaining for S-100 protein, cytokeratin, and muscle-specific actin, as well as the ultrastructural presence of intermediate filaments with dense bodies and intercellular junctions, supported the predominant myoepithelial cell differentiation within the tumor, whereas the epithelial cell component stained only with cytokeratin and contained formed lumina with surface microvilli. The DNA pattern was diploid. The patient is alive and well 14 months after surgery. The authors' findings confirm that plemorphic adenoma of the breast is a benign neoplasm in which myoepithelial cell proliferation plays a major role in tumorogenesis.

KW - Benign mixed tumor

KW - Breast neoplasm

KW - Pleomorphic adenoma

UR - http://www.scopus.com/inward/record.url?scp=0025299627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025299627&partnerID=8YFLogxK

M3 - Article

VL - 93

SP - 795

EP - 801

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 6

ER -