Pleomorphic adenoma (benign mixed tumor) of the breast. An immunohistochemical, flow cytometric, and ultrastructural study and review of the literature

W. A. Ballance, J. Y. Ro, A. K. El-Naggar, D. J. Grignon, A. G. Ayala, M. G. Romsdahl

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Pleomorphic adenoma (or benign mixed tumor) of the breast is a rare benign neoplasm that might be misinterpreted both clinically and pathologically as a malignant tumor. The authors present an additional case of this unusual lesion studied by immunohistochemistry, electron microscopy, and flow cytometry. A 77-year-old white woman presented with a 2-cm, nontender, mobile, calcified, right subareolar mass suggestive of a fibroadenoma. Microscopically, the tumor resembled a pleomorphic adenoma occurring in salivary glands. Positive immunostaining for S-100 protein, cytokeratin, and muscle-specific actin, as well as the ultrastructural presence of intermediate filaments with dense bodies and intercellular junctions, supported the predominant myoepithelial cell differentiation within the tumor, whereas the epithelial cell component stained only with cytokeratin and contained formed lumina with surface microvilli. The DNA pattern was diploid. The patient is alive and well 14 months after surgery. The authors' findings confirm that plemorphic adenoma of the breast is a benign neoplasm in which myoepithelial cell proliferation plays a major role in tumorogenesis.

Original languageEnglish (US)
Pages (from-to)795-801
Number of pages7
JournalAmerican journal of clinical pathology
Volume93
Issue number6
DOIs
StatePublished - Jan 1 1990

Keywords

  • Benign mixed tumor
  • Breast neoplasm
  • Pleomorphic adenoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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