Pluripotent tumor cells in benign pituitary adenomas associated with multiple endocrine neoplasia type 1

Robert J. Weil, Steve Huang, Svetlana Pack, Alexander O. Vortmeyer, Maria Tsokos, Irina A. Lubensky, Edward H. Oldfield, Zhengping Zhuang

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Analysis of human tumor cells in vitro enhances the study of numerous neoplastic conditions. However, it has been difficult to establish long-term cultures of adenoma cells, especially those of neuroendocrine origin, because the endocrine cells survive only briefly in culture, and fibroblasts overgrow the culture dish in 1 or 2 weeks. We describe cells isolated from pituitary adenomas in two patients with multiple endocrine neoplasia type 1 in which cells with a mesenchymal phenotype evolved from pituitary tumor cells. It appears that these poorly differentiated cells arose from multipotent adenoma cells. This represents a path of cell differentiation not observed previously in humans and may help explain the diverse nature of the benign tumors in multiple endocrine neoplasia type 1.

Original languageEnglish (US)
Pages (from-to)4715-4720
Number of pages6
JournalCancer Research
Volume58
Issue number20
StatePublished - Oct 15 1998
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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