Pneumocystis carinii is resistant to imidazole antifungal agents

M. S. Bartlett, Sherry Queener, M. M. Shaw, J. D. Richardson, J. W. Smith

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Because Pneumocystis carinii is closely related to fungi, drugs useful for treating mycoses have been considered for use in the treatment of P. carinii pneumonia. Six antifungal imidazole drugs were tested for their activities against P. carinii in a short-term culture screen and in animals. None of the imidazoles tested was effective in inoculated infected rats, and only miconazole showed slight effects in culture at the high concentration of 10 μg/ml. Analysis of cell membranes from culture-grown P. carinii showed that ergosterol, the target for this class of antifungal agents, was absent, so that the lack of effect of these agents is rational.

Original languageEnglish
Pages (from-to)1859-1861
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume38
Issue number8
StatePublished - 1994

Fingerprint

Pneumocystis carinii
Antifungal Agents
Imidazoles
Miconazole
Ergosterol
Pneumocystis Pneumonia
Mycoses
Pharmaceutical Preparations
Fungi
Cell Culture Techniques
Cell Membrane
imidazole

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Bartlett, M. S., Queener, S., Shaw, M. M., Richardson, J. D., & Smith, J. W. (1994). Pneumocystis carinii is resistant to imidazole antifungal agents. Antimicrobial Agents and Chemotherapy, 38(8), 1859-1861.

Pneumocystis carinii is resistant to imidazole antifungal agents. / Bartlett, M. S.; Queener, Sherry; Shaw, M. M.; Richardson, J. D.; Smith, J. W.

In: Antimicrobial Agents and Chemotherapy, Vol. 38, No. 8, 1994, p. 1859-1861.

Research output: Contribution to journalArticle

Bartlett, MS, Queener, S, Shaw, MM, Richardson, JD & Smith, JW 1994, 'Pneumocystis carinii is resistant to imidazole antifungal agents', Antimicrobial Agents and Chemotherapy, vol. 38, no. 8, pp. 1859-1861.
Bartlett, M. S. ; Queener, Sherry ; Shaw, M. M. ; Richardson, J. D. ; Smith, J. W. / Pneumocystis carinii is resistant to imidazole antifungal agents. In: Antimicrobial Agents and Chemotherapy. 1994 ; Vol. 38, No. 8. pp. 1859-1861.
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