Pneumocystis carinii is resistant to imidazole antifungal agents

M. S. Bartlett, S. F. Queener, M. M. Shaw, J. D. Richardson, J. W. Smith

Research output: Contribution to journalComment/debate

37 Scopus citations

Abstract

Because Pneumocystis carinii is closely related to fungi, drugs useful for treating mycoses have been considered for use in the treatment of P. carinii pneumonia. Six antifungal imidazole drugs were tested for their activities against P. carinii in a short-term culture screen and in animals. None of the imidazoles tested was effective in inoculated infected rats, and only miconazole showed slight effects in culture at the high concentration of 10 μg/ml. Analysis of cell membranes from culture-grown P. carinii showed that ergosterol, the target for this class of antifungal agents, was absent, so that the lack of effect of these agents is rational.

Original languageEnglish (US)
Pages (from-to)1859-1861
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume38
Issue number8
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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