Pneumocystis carinii pneumonia therapy with 9-deazainosine in rats

James W. Smith, Marilyn S. Bartlett, Sherry F. Queener, Michelle M. Durkin, Margaret A. Jay, Meredith T. Hull, Robert S. Klein, J. Joseph Marr

Research output: Contribution to journalArticle

18 Scopus citations


An inosine analog, 9-deazainosine, has previously been demonstrated to inhibit Pneumocystis carinii in culture with WI-38 cells. The present study shows that it is also effective against Pneumocystis carinii in immunosuppressed Sprague-Dawley rats with Pneumocystis carinii pneumonia. After 8 wk of immunosuppression, rats that developed severe Pneumocystis carinii pneumonia were treated with either 9-deazainosine or served as controls. After 15 days of therapy, animals were sacrificed and severity of infection determined by morphologic examination of lungs for numbers of Pneumocystis carinii. Treated animals had greatly reduced numbers of Pneumocystis carinii trophozoites and cysts, compared with controls. This drug shows promise for therapy of Pneumocystis carinii pneumonia and should be studied further.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Issue number2
StatePublished - Jun 1987
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Smith, J. W., Bartlett, M. S., Queener, S. F., Durkin, M. M., Jay, M. A., Hull, M. T., Klein, R. S., & Marr, J. J. (1987). Pneumocystis carinii pneumonia therapy with 9-deazainosine in rats. Diagnostic Microbiology and Infectious Disease, 7(2), 113-118.