Pneumocystis carinii pneumonia therapy with 9-deazainosine in rats

James W. Smith, Marilyn S. Bartlett, Sherry Queener, Michelle M. Durkin, Margaret A. Jay, Meredith T. Hull, Robert S. Klein, J. Joseph Marr

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

An inosine analog, 9-deazainosine, has previously been demonstrated to inhibit Pneumocystis carinii in culture with WI-38 cells. The present study shows that it is also effective against Pneumocystis carinii in immunosuppressed Sprague-Dawley rats with Pneumocystis carinii pneumonia. After 8 wk of immunosuppression, rats that developed severe Pneumocystis carinii pneumonia were treated with either 9-deazainosine or served as controls. After 15 days of therapy, animals were sacrificed and severity of infection determined by morphologic examination of lungs for numbers of Pneumocystis carinii. Treated animals had greatly reduced numbers of Pneumocystis carinii trophozoites and cysts, compared with controls. This drug shows promise for therapy of Pneumocystis carinii pneumonia and should be studied further.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume7
Issue number2
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Pneumocystis carinii
Pneumocystis Pneumonia
Inosine
Trophozoites
Therapeutics
Immunosuppression
Sprague Dawley Rats
Cysts
Lung
9-deazainosine
Infection
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Smith, J. W., Bartlett, M. S., Queener, S., Durkin, M. M., Jay, M. A., Hull, M. T., ... Marr, J. J. (1987). Pneumocystis carinii pneumonia therapy with 9-deazainosine in rats. Diagnostic Microbiology and Infectious Disease, 7(2), 113-118. https://doi.org/10.1016/0732-8893(87)90028-9

Pneumocystis carinii pneumonia therapy with 9-deazainosine in rats. / Smith, James W.; Bartlett, Marilyn S.; Queener, Sherry; Durkin, Michelle M.; Jay, Margaret A.; Hull, Meredith T.; Klein, Robert S.; Marr, J. Joseph.

In: Diagnostic Microbiology and Infectious Disease, Vol. 7, No. 2, 1987, p. 113-118.

Research output: Contribution to journalArticle

Smith, JW, Bartlett, MS, Queener, S, Durkin, MM, Jay, MA, Hull, MT, Klein, RS & Marr, JJ 1987, 'Pneumocystis carinii pneumonia therapy with 9-deazainosine in rats', Diagnostic Microbiology and Infectious Disease, vol. 7, no. 2, pp. 113-118. https://doi.org/10.1016/0732-8893(87)90028-9
Smith, James W. ; Bartlett, Marilyn S. ; Queener, Sherry ; Durkin, Michelle M. ; Jay, Margaret A. ; Hull, Meredith T. ; Klein, Robert S. ; Marr, J. Joseph. / Pneumocystis carinii pneumonia therapy with 9-deazainosine in rats. In: Diagnostic Microbiology and Infectious Disease. 1987 ; Vol. 7, No. 2. pp. 113-118.
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