Point: Counterpoint: Alterations in airway smooth muscle phenotype do/do not cause airway hyperresponsiveness in asthma

Susan Gunst, Reynold A. Panettieri

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Summary. Airway hyperresponsiveness and obstruction are cardinal features of asthma. Compelling evidence now suggests that the key features of asthma in part are due to intrinsic differences in airway smooth muscle (ASM) function. Inflammatory mediators alter ASM phenotype, which directly modulates ASM hyperresponsiveness and promotes airway remodeling that further contributes to amplified airway obstruction. For decades, the most effective and common therapies in the management of asthma have focused on bronchodilation and reversal of ASM shortening. Accordingly, alterations in the phenotype of ASM, the pivotal cell regulating bronchomotor tone, fundamentally contribute to airway hyperresponsiveness in asthma.

Original languageEnglish
Pages (from-to)837-839
Number of pages3
JournalJournal of Applied Physiology
Volume113
Issue number5
DOIs
StatePublished - Sep 1 2012

Fingerprint

Smooth Muscle
Asthma
Phenotype
Airway Obstruction
Airway Remodeling
Smooth Muscle Myocytes
Therapeutics

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Medicine(all)

Cite this

Point : Counterpoint: Alterations in airway smooth muscle phenotype do/do not cause airway hyperresponsiveness in asthma. / Gunst, Susan; Panettieri, Reynold A.

In: Journal of Applied Physiology, Vol. 113, No. 5, 01.09.2012, p. 837-839.

Research output: Contribution to journalArticle

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