Polycystic ovary syndrome is associated with endothelial dysfunction

Giancarlo Paradisi, Helmut O. Steinberg, Annette Hempfling, Jessica Cronin, Ginger Hook, Marguerite Shepard, Alain D. Baron

Research output: Contribution to journalArticle

345 Citations (Scopus)

Abstract

Background - We recently reported endothelial dysfunction as a novel cardiovascular risk factor associated with insulin resistance/obesity. Here, we tested whether hyperandrogenic insulin-resistant women with polycystic ovary syndrome (PCOS) who are at increased risk of macrovascular disease display impaired endothelium-dependent vasodilation and whether endothelial function in PCOS is associated with particular metabolic and/or hormonal characteristics. Methods and Results - We studied leg blood flow (LBF) responses to graded intrafemoral artery infusions of the endothelium-dependent vasodilator methacholine chloride (MCh) and to euglycemic hyperinsulinemia in 12 obese women with PCOS and in 13 healthy age- and weight-matched control subjects (OBW). LBF increments in response to MCh were 50% lower in the PCOS group than in the OBW group (P<0.01). Euglycemic hyperinsulinemia increased LBF above baseline by 30% in the PCOS and 60% in OBW group (P<0.05 between groups). Across all subjects, the maximal LBF response to MCh exhibited a strong inverse correlation with free testosterone levels (r=-0.52, P<0.007). This relationship was stronger than with any other parameter, including insulin sensitivity. Conclusions - PCOS is characterized by (1) endothelial dysfunction and (2) resistance to the vasodilating action of insulin. This endothelial dysfunction appears to be associated with both elevated androgen levels and insulin resistance. Given the central vasoprotective role of endothelium, these findings could explain, at least in part, the increased risk for macrovascular disease in women with PCOS.

Original languageEnglish
Pages (from-to)1410-1415
Number of pages6
JournalCirculation
Volume103
Issue number10
StatePublished - Mar 13 2001

Fingerprint

Polycystic Ovary Syndrome
Methacholine Chloride
Leg
Insulin Resistance
Hyperinsulinism
Endothelium
Insulin
Endothelium-Dependent Relaxing Factors
Vasodilation
Androgens
Testosterone
Arteries
Obesity
Weights and Measures

Keywords

  • Blood flow
  • Glucose
  • Hormones
  • Insulin
  • Nitric oxide

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Paradisi, G., Steinberg, H. O., Hempfling, A., Cronin, J., Hook, G., Shepard, M., & Baron, A. D. (2001). Polycystic ovary syndrome is associated with endothelial dysfunction. Circulation, 103(10), 1410-1415.

Polycystic ovary syndrome is associated with endothelial dysfunction. / Paradisi, Giancarlo; Steinberg, Helmut O.; Hempfling, Annette; Cronin, Jessica; Hook, Ginger; Shepard, Marguerite; Baron, Alain D.

In: Circulation, Vol. 103, No. 10, 13.03.2001, p. 1410-1415.

Research output: Contribution to journalArticle

Paradisi, G, Steinberg, HO, Hempfling, A, Cronin, J, Hook, G, Shepard, M & Baron, AD 2001, 'Polycystic ovary syndrome is associated with endothelial dysfunction', Circulation, vol. 103, no. 10, pp. 1410-1415.
Paradisi G, Steinberg HO, Hempfling A, Cronin J, Hook G, Shepard M et al. Polycystic ovary syndrome is associated with endothelial dysfunction. Circulation. 2001 Mar 13;103(10):1410-1415.
Paradisi, Giancarlo ; Steinberg, Helmut O. ; Hempfling, Annette ; Cronin, Jessica ; Hook, Ginger ; Shepard, Marguerite ; Baron, Alain D. / Polycystic ovary syndrome is associated with endothelial dysfunction. In: Circulation. 2001 ; Vol. 103, No. 10. pp. 1410-1415.
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