Polyethylene and heparin coated polyethylene in a canine A-A shunt model. Effects on blood flow as a measure of thrombogenicity

N. D. Macon, G. E. Sandusky, N. A. Bryan, R. S. Nevin, D. J. Allen, M. B. Michaels

Research output: Contribution to conferencePaperpeer-review

Abstract

The objective of this study was to determine whether heparin surface treatment via ionic or covalent immobilization would significantly improve the thrombogenicity characteristics of polyethylene, as observed in an acute preparation using a canine A-A shunt model. The effects of the surface treatments on blood flow over five hours as well as histology data taken from the vascular test sites were evaluated as indicators of thrombogenicity. It is shown that the two heparin coatings did not significantly alter the blood-material interaction characteristics for polyethylene shunts as observed in a canine model over an acute time period of approximately five hours. Histologic studies of arterial wall changes under similar conditions have focused on long term injury effects of chronic catheterization.

Original languageEnglish (US)
Number of pages1
StatePublished - Jan 1 1991
Externally publishedYes
Event17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium - Scottsdale, AZ, USA
Duration: May 1 1991May 5 1991

Other

Other17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium
CityScottsdale, AZ, USA
Period5/1/915/5/91

ASJC Scopus subject areas

  • Materials Science(all)

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