Polygenic and single-gene determination of responses to ethanol in BXD/Ty recombinant inbred mouse strains

J. C. Crabbe, Ann Kosobud, E. R. Young, J. S. Janowsky

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Male mice of parent inbred strains C57BL/6J and DBA/2J, and mice from several of the BXD/Ty Recombinant Inbred (RI) strains derived from the cross of the parent inbred strains were tested for responsiveness to ethanol. Separate groups of mice from these strains were characterized for sensitivity to ethanol's effects to increase activity in an open field and to induce ambulatory ataxia in the grid test. The strain distribution pattern of the RI strains indicated polygenic control of both responses to ethanol. Other mice from this battery were tested for acceptance of an ethanol solution, a measure related to preference drinking. This trait may be substantially influenced by a single gene. Mice were then rendered physically dependent on ethanol through inhalation of ethanol vapor for three days. Severity of handling-induced convulsions was used to index the severity of the ethanol withdrawal syndrome. The distribution of the RI strains indicated possible influence of a major gene on ethanol withdrawal severity.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalNeurobehavioral Toxicology and Teratology
Volume5
Issue number2
StatePublished - 1983
Externally publishedYes

Fingerprint

Inbred Strains Mice
Ethanol
Genes
Inbred DBA Mouse
Ataxia
Inhalation
Drinking
Seizures
Vapors

ASJC Scopus subject areas

  • Embryology
  • Toxicology
  • Neuropsychology and Physiological Psychology

Cite this

Polygenic and single-gene determination of responses to ethanol in BXD/Ty recombinant inbred mouse strains. / Crabbe, J. C.; Kosobud, Ann; Young, E. R.; Janowsky, J. S.

In: Neurobehavioral Toxicology and Teratology, Vol. 5, No. 2, 1983, p. 181-187.

Research output: Contribution to journalArticle

@article{011ac1c666ed477983783f091c886a76,
title = "Polygenic and single-gene determination of responses to ethanol in BXD/Ty recombinant inbred mouse strains",
abstract = "Male mice of parent inbred strains C57BL/6J and DBA/2J, and mice from several of the BXD/Ty Recombinant Inbred (RI) strains derived from the cross of the parent inbred strains were tested for responsiveness to ethanol. Separate groups of mice from these strains were characterized for sensitivity to ethanol's effects to increase activity in an open field and to induce ambulatory ataxia in the grid test. The strain distribution pattern of the RI strains indicated polygenic control of both responses to ethanol. Other mice from this battery were tested for acceptance of an ethanol solution, a measure related to preference drinking. This trait may be substantially influenced by a single gene. Mice were then rendered physically dependent on ethanol through inhalation of ethanol vapor for three days. Severity of handling-induced convulsions was used to index the severity of the ethanol withdrawal syndrome. The distribution of the RI strains indicated possible influence of a major gene on ethanol withdrawal severity.",
author = "Crabbe, {J. C.} and Ann Kosobud and Young, {E. R.} and Janowsky, {J. S.}",
year = "1983",
language = "English",
volume = "5",
pages = "181--187",
journal = "Neurotoxicology and Teratology",
issn = "0892-0362",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Polygenic and single-gene determination of responses to ethanol in BXD/Ty recombinant inbred mouse strains

AU - Crabbe, J. C.

AU - Kosobud, Ann

AU - Young, E. R.

AU - Janowsky, J. S.

PY - 1983

Y1 - 1983

N2 - Male mice of parent inbred strains C57BL/6J and DBA/2J, and mice from several of the BXD/Ty Recombinant Inbred (RI) strains derived from the cross of the parent inbred strains were tested for responsiveness to ethanol. Separate groups of mice from these strains were characterized for sensitivity to ethanol's effects to increase activity in an open field and to induce ambulatory ataxia in the grid test. The strain distribution pattern of the RI strains indicated polygenic control of both responses to ethanol. Other mice from this battery were tested for acceptance of an ethanol solution, a measure related to preference drinking. This trait may be substantially influenced by a single gene. Mice were then rendered physically dependent on ethanol through inhalation of ethanol vapor for three days. Severity of handling-induced convulsions was used to index the severity of the ethanol withdrawal syndrome. The distribution of the RI strains indicated possible influence of a major gene on ethanol withdrawal severity.

AB - Male mice of parent inbred strains C57BL/6J and DBA/2J, and mice from several of the BXD/Ty Recombinant Inbred (RI) strains derived from the cross of the parent inbred strains were tested for responsiveness to ethanol. Separate groups of mice from these strains were characterized for sensitivity to ethanol's effects to increase activity in an open field and to induce ambulatory ataxia in the grid test. The strain distribution pattern of the RI strains indicated polygenic control of both responses to ethanol. Other mice from this battery were tested for acceptance of an ethanol solution, a measure related to preference drinking. This trait may be substantially influenced by a single gene. Mice were then rendered physically dependent on ethanol through inhalation of ethanol vapor for three days. Severity of handling-induced convulsions was used to index the severity of the ethanol withdrawal syndrome. The distribution of the RI strains indicated possible influence of a major gene on ethanol withdrawal severity.

UR - http://www.scopus.com/inward/record.url?scp=0020641441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020641441&partnerID=8YFLogxK

M3 - Article

C2 - 6683363

AN - SCOPUS:0020641441

VL - 5

SP - 181

EP - 187

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

SN - 0892-0362

IS - 2

ER -