Polygenic risk scores in psychiatry: Will they be useful for clinicians? [version 1; peer review: 4 approved]

Janice M. Fullerton, John Nurnberger

Research output: Contribution to journalReview article

Abstract

Major psychiatric disorders are heritable but they are genetically complex. This means that, with certain exceptions, single gene markers will not be helpful for diagnosis. However, we are learning more about the large number of gene variants that, in combination, are associated with risk for disorders such as schizophrenia, bipolar disorder, and other psychiatric conditions. The presence of those risk variants may now be combined into a polygenic risk score (PRS). Such a score provides a quantitative index of the genomic burden of risk variants in an individual, which relates to the likelihood that a person has a particular disorder. Currently, such scores are quite useful in research, and they are telling us much about the relationships between different disorders and other indices of brain function. In the future, as the datasets supporting the development of such scores become larger and more diverse and as methodological developments improve predictive capacity, we expect that PRS will have substantial clinical utility in the assessment of risk for disease, subtypes of disease, and even treatment response. Here, we provide an overview of PRS in general terms (including a glossary suitable for informed non-geneticists) and discuss the use of PRS in psychiatry, including their limitations and cautions for interpretation, as well as their applications now and in the future.

Original languageEnglish (US)
Article number1293
JournalF1000Research
Volume8
DOIs
StatePublished - Jan 1 2019

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Peer Review
Psychiatry
Genes
Bipolar Disorder
Glossaries
Schizophrenia
Brain
Learning
Research

Keywords

  • Clinical practice
  • Genetics
  • Polygenic risk scores
  • Psychiatry

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Polygenic risk scores in psychiatry : Will they be useful for clinicians? [version 1; peer review: 4 approved]. / Fullerton, Janice M.; Nurnberger, John.

In: F1000Research, Vol. 8, 1293, 01.01.2019.

Research output: Contribution to journalReview article

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