Polymorphism and conservation of the genes encoding Qa1 molecules

Evan Hermel, Andrew J. Hart, Irfan Gunduz, Hector Acton, Christina Kim, Mark Wurth, Samina Uddin, Caryn Smith, Kirsten Fischer Lindahl, Carla Aldrich

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

To evaluate the polymorphism and conservation of the major histocompatibility complex class Ib molecule Qa1 in wild mouse populations, we determined the nucleotide sequence of exons 1-3 of Qa1 of eight mouse haplotypes derived from wild mice, including Mus musculus domesticus, M. m. castaneus, M. m. bactrianus, and M. spretus, as well as two t haplotypes. Our data identify eight new alleles of Qa1. Taken together with previously published data on Qa1 among the common laboratory inbred strains, and in agreement with cytotoxic T-lymphocyte, serological, and biochemical data, these results further confirm the existence of two families of Qa1 molecules, Qa1a-like and Qa1b-like, and illuminate the extreme conservation of the peptide-binding region of these molecules, even across species.

Original languageEnglish
Pages (from-to)639-649
Number of pages11
JournalImmunogenetics
Volume56
Issue number9
DOIs
StatePublished - Dec 2004

Fingerprint

Haplotypes
Genes
Cytotoxic T-Lymphocytes
Major Histocompatibility Complex
Exons
Alleles
Peptides
Population

Keywords

  • Cytotoxic T lymphocyte
  • H2-Qa1
  • H2-T23
  • MHC class Ib
  • Mus spretus
  • Wild mice

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Hermel, E., Hart, A. J., Gunduz, I., Acton, H., Kim, C., Wurth, M., ... Aldrich, C. (2004). Polymorphism and conservation of the genes encoding Qa1 molecules. Immunogenetics, 56(9), 639-649. https://doi.org/10.1007/s00251-004-0722-x

Polymorphism and conservation of the genes encoding Qa1 molecules. / Hermel, Evan; Hart, Andrew J.; Gunduz, Irfan; Acton, Hector; Kim, Christina; Wurth, Mark; Uddin, Samina; Smith, Caryn; Lindahl, Kirsten Fischer; Aldrich, Carla.

In: Immunogenetics, Vol. 56, No. 9, 12.2004, p. 639-649.

Research output: Contribution to journalArticle

Hermel, E, Hart, AJ, Gunduz, I, Acton, H, Kim, C, Wurth, M, Uddin, S, Smith, C, Lindahl, KF & Aldrich, C 2004, 'Polymorphism and conservation of the genes encoding Qa1 molecules', Immunogenetics, vol. 56, no. 9, pp. 639-649. https://doi.org/10.1007/s00251-004-0722-x
Hermel E, Hart AJ, Gunduz I, Acton H, Kim C, Wurth M et al. Polymorphism and conservation of the genes encoding Qa1 molecules. Immunogenetics. 2004 Dec;56(9):639-649. https://doi.org/10.1007/s00251-004-0722-x
Hermel, Evan ; Hart, Andrew J. ; Gunduz, Irfan ; Acton, Hector ; Kim, Christina ; Wurth, Mark ; Uddin, Samina ; Smith, Caryn ; Lindahl, Kirsten Fischer ; Aldrich, Carla. / Polymorphism and conservation of the genes encoding Qa1 molecules. In: Immunogenetics. 2004 ; Vol. 56, No. 9. pp. 639-649.
@article{65931da7ba9b4a9792c43c50102ce010,
title = "Polymorphism and conservation of the genes encoding Qa1 molecules",
abstract = "To evaluate the polymorphism and conservation of the major histocompatibility complex class Ib molecule Qa1 in wild mouse populations, we determined the nucleotide sequence of exons 1-3 of Qa1 of eight mouse haplotypes derived from wild mice, including Mus musculus domesticus, M. m. castaneus, M. m. bactrianus, and M. spretus, as well as two t haplotypes. Our data identify eight new alleles of Qa1. Taken together with previously published data on Qa1 among the common laboratory inbred strains, and in agreement with cytotoxic T-lymphocyte, serological, and biochemical data, these results further confirm the existence of two families of Qa1 molecules, Qa1a-like and Qa1b-like, and illuminate the extreme conservation of the peptide-binding region of these molecules, even across species.",
keywords = "Cytotoxic T lymphocyte, H2-Qa1, H2-T23, MHC class Ib, Mus spretus, Wild mice",
author = "Evan Hermel and Hart, {Andrew J.} and Irfan Gunduz and Hector Acton and Christina Kim and Mark Wurth and Samina Uddin and Caryn Smith and Lindahl, {Kirsten Fischer} and Carla Aldrich",
year = "2004",
month = "12",
doi = "10.1007/s00251-004-0722-x",
language = "English",
volume = "56",
pages = "639--649",
journal = "Immunogenetics",
issn = "0093-7711",
publisher = "Springer Verlag",
number = "9",

}

TY - JOUR

T1 - Polymorphism and conservation of the genes encoding Qa1 molecules

AU - Hermel, Evan

AU - Hart, Andrew J.

AU - Gunduz, Irfan

AU - Acton, Hector

AU - Kim, Christina

AU - Wurth, Mark

AU - Uddin, Samina

AU - Smith, Caryn

AU - Lindahl, Kirsten Fischer

AU - Aldrich, Carla

PY - 2004/12

Y1 - 2004/12

N2 - To evaluate the polymorphism and conservation of the major histocompatibility complex class Ib molecule Qa1 in wild mouse populations, we determined the nucleotide sequence of exons 1-3 of Qa1 of eight mouse haplotypes derived from wild mice, including Mus musculus domesticus, M. m. castaneus, M. m. bactrianus, and M. spretus, as well as two t haplotypes. Our data identify eight new alleles of Qa1. Taken together with previously published data on Qa1 among the common laboratory inbred strains, and in agreement with cytotoxic T-lymphocyte, serological, and biochemical data, these results further confirm the existence of two families of Qa1 molecules, Qa1a-like and Qa1b-like, and illuminate the extreme conservation of the peptide-binding region of these molecules, even across species.

AB - To evaluate the polymorphism and conservation of the major histocompatibility complex class Ib molecule Qa1 in wild mouse populations, we determined the nucleotide sequence of exons 1-3 of Qa1 of eight mouse haplotypes derived from wild mice, including Mus musculus domesticus, M. m. castaneus, M. m. bactrianus, and M. spretus, as well as two t haplotypes. Our data identify eight new alleles of Qa1. Taken together with previously published data on Qa1 among the common laboratory inbred strains, and in agreement with cytotoxic T-lymphocyte, serological, and biochemical data, these results further confirm the existence of two families of Qa1 molecules, Qa1a-like and Qa1b-like, and illuminate the extreme conservation of the peptide-binding region of these molecules, even across species.

KW - Cytotoxic T lymphocyte

KW - H2-Qa1

KW - H2-T23

KW - MHC class Ib

KW - Mus spretus

KW - Wild mice

UR - http://www.scopus.com/inward/record.url?scp=19944426423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19944426423&partnerID=8YFLogxK

U2 - 10.1007/s00251-004-0722-x

DO - 10.1007/s00251-004-0722-x

M3 - Article

C2 - 15517242

AN - SCOPUS:19944426423

VL - 56

SP - 639

EP - 649

JO - Immunogenetics

JF - Immunogenetics

SN - 0093-7711

IS - 9

ER -