Polymorphisms in inflammatory genes, plasma antioxidants, and prostate cancer risk

Jianjun Zhang , Ishwori B. Dhakal, Nicholas P. Lang, Fred F. Kadlubar

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Presence of xenotropic murine leukemia virus-related virus and chronic inflammation in prostate tumor suggests that inflammation plays a role in prostate cancer etiology. This study investigated whether variants in inflammatory genes act alone or interact with plasma antioxidants to influence prostate cancer risk in a population-based case-control study in Central Arkansas. Methods: Cases (n = 193) were men, aged 40-80, diagnosed with prostate cancer in three major hospitals in 1998-2003, and controls (n = 197) were matched to cases by age, race, and county of residence. Results: After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs4073) were not significantly associated with prostate cancer risk. However, apparent interactions were observed between these genetic variants and plasma antioxidants on the risk of this malignancy. The protective effect of the mutant allele of the COX-2 polymorphism was more pronounced among subjects with high plasma levels of β-cryptoxanthin, lycopene, β-carotene, or selenium (≥median) [e.g., OR (95% CI): 0.37 (0.15, 0.86) (AG/GG vs. AA) for β-cryptoxanthin]. Conversely, the promoting effect of the variant allele of the IL-8 polymorphism was more remarkable in subjects with low plasma levels of Lutein/zeaxanthin, β-cryptoxanthin, and β-carotene (

Original languageEnglish (US)
Pages (from-to)1437-1444
Number of pages8
JournalCancer Causes and Control
Volume21
Issue number9
DOIs
StatePublished - Sep 2010
Externally publishedYes

Fingerprint

Prostatic Neoplasms
Antioxidants
Carotenoids
Interleukin-8
Genes
Xenotropic murine leukemia virus-related virus
Alleles
Inflammation
Lutein
Selenium
Case-Control Studies
Prostate
Neoplasms
Population
Cryptoxanthins

Keywords

  • Antioxidants
  • Inflammatory gene
  • Oxidative stress
  • Polymorphism
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Polymorphisms in inflammatory genes, plasma antioxidants, and prostate cancer risk. / Zhang , Jianjun; Dhakal, Ishwori B.; Lang, Nicholas P.; Kadlubar, Fred F.

In: Cancer Causes and Control, Vol. 21, No. 9, 09.2010, p. 1437-1444.

Research output: Contribution to journalArticle

Zhang , Jianjun ; Dhakal, Ishwori B. ; Lang, Nicholas P. ; Kadlubar, Fred F. / Polymorphisms in inflammatory genes, plasma antioxidants, and prostate cancer risk. In: Cancer Causes and Control. 2010 ; Vol. 21, No. 9. pp. 1437-1444.
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