Polypoid and papillary epithelial hyperplasia: A potential cause of ductal obstruction in adult polycystic disease

Andrew Evan, K. D. Gardner, J. Bernstein

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

In experimental models of cystic renal disease, functional studies define conditions that suggest increased resistance to outflow from dilated or cystic nephrons. Morphologically, models exhibit foci of cellular hyperplasia and micropolyp formation along outer medullary collecting tubules. Temporally, cellular proliferation precedes cyst formation. These findings in models have led to a hypothesis that polypoid hyperplasia participates in cyst formation in susceptible kidneys by increasing resistance to the outflow of tubular urine. The present study was undertaken to establish the presence, extent, and distribution of cellular hyperplasia in human adult polycystic kidney disease. Kidneys from 4 unrelated individuals were studied by light and by transmission and scanning electron microscopy. Foci of hyperplasia were found in all. Cellular and subcellular detail and the location of hyperplasia along the nephron were similar to those seen in the models. These findings delineate a heretofore unappreciated morphologic similarity between the models and human disease and add further support to the hypothesis that partial tubular obstruction participates in the pathogenesis of renal cystic disease, whether it be heritable or acquired, in animals and in man.

Original languageEnglish (US)
Pages (from-to)743-750
Number of pages8
JournalKidney International
Volume16
Issue number6
StatePublished - 1979
Externally publishedYes

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Hyperplasia
Cystic Kidney Diseases
Nephrons
Cysts
Kidney
Autosomal Dominant Polycystic Kidney
Scanning Transmission Electron Microscopy
Theoretical Models
Cell Proliferation
Urine
Light

ASJC Scopus subject areas

  • Nephrology

Cite this

Polypoid and papillary epithelial hyperplasia : A potential cause of ductal obstruction in adult polycystic disease. / Evan, Andrew; Gardner, K. D.; Bernstein, J.

In: Kidney International, Vol. 16, No. 6, 1979, p. 743-750.

Research output: Contribution to journalArticle

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