Population-based study of pelvic lymph node positivity in clinically localized prostate cancer: A study comparing African Americans and Whites

Ubirajara Barroso, Peter Oskanian, Marcos V. Tefilli, Mousumi Banerjee, David Grignon, Wael Sakr, Jose Edson Pontes, Isaac J. Powell

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives. To evaluate the correlation between race and lymph node metastasis for prostate cancer by analyzing which preoperative parameters may predict lymph node status in both races. Methods. We analyzed a group of patients (552 American white men [AWM] and 423 African-American men [AAM]) who underwent radical prostatectomy plus modified pelvic lymphadenectomy between January 1991 and June 1997. Patients who received neoadjuvant radiation or hormone therapy were excluded. Univariate and multivariate analyses were performed to determine the influence of race on lymph node positivity, as well as to correlate the preoperative parameters (serum prostate-specific antigen [PSA], biopsy Gleason score, and clinical stage) with lymph node metastasis for each race separately. Results. The AAM presented with significantly higher preoperative Gleason scores and PSA levels than AWM. However, comparing lymph node status by race, the difference of positivity (41 AWM [7.4%] and 22 AAM [5.2%]) was not statistically significant (P = 0.16). The percentage of positive nodes was similar in both races for each subset of PSA, Gleason score, and clinical stage. Despite the statistical significance of the three preoperative parameters in univariate analysis, in multivariate analysis only PSA and Gleason score were independent predictors of positive lymph nodes. Conclusions. There is no influence of race on lymph node metastasis, despite AAM presenting with higher preoperative Gleason scores and PSA levels. In multivariate analysis, preoperative Gleason score and PSA were independent factors for positive nodes regardless of race.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalUrology
Volume53
Issue number1
DOIs
StatePublished - Jan 1 1999

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African Americans
Neoplasm Grading
Prostatic Neoplasms
Prostate-Specific Antigen
Lymph Nodes
Population
Multivariate Analysis
Neoplasm Metastasis
Prostatectomy
Lymph Node Excision
Hormones
Radiation
Biopsy
Serum

ASJC Scopus subject areas

  • Urology

Cite this

Population-based study of pelvic lymph node positivity in clinically localized prostate cancer : A study comparing African Americans and Whites. / Barroso, Ubirajara; Oskanian, Peter; Tefilli, Marcos V.; Banerjee, Mousumi; Grignon, David; Sakr, Wael; Pontes, Jose Edson; Powell, Isaac J.

In: Urology, Vol. 53, No. 1, 01.01.1999, p. 187-191.

Research output: Contribution to journalArticle

Barroso, U, Oskanian, P, Tefilli, MV, Banerjee, M, Grignon, D, Sakr, W, Pontes, JE & Powell, IJ 1999, 'Population-based study of pelvic lymph node positivity in clinically localized prostate cancer: A study comparing African Americans and Whites', Urology, vol. 53, no. 1, pp. 187-191. https://doi.org/10.1016/S0090-4295(98)00441-5
Barroso, Ubirajara ; Oskanian, Peter ; Tefilli, Marcos V. ; Banerjee, Mousumi ; Grignon, David ; Sakr, Wael ; Pontes, Jose Edson ; Powell, Isaac J. / Population-based study of pelvic lymph node positivity in clinically localized prostate cancer : A study comparing African Americans and Whites. In: Urology. 1999 ; Vol. 53, No. 1. pp. 187-191.
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