Post-chemotherapy resection of nonseminomatous germ cell testicular tumors metastatic to the mediastinum

Mohamed J. Hejase, John P. Donohue, Richard Foster, Richard Bihrle, Christopher L. Coogan, Randall G. Rowland, Gregory R. Wahle

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: We determined if the behavior of germ cell tumors metastatic to the mediastinum is different from that of primary mediastinal germ cell tumors, a group known to have distinct clinical features. Materials and Methods: A search of the computerized data base for germ cell tumors metastatic to the mediastinum at our university revealed 80 patients, 65 of whom underwent concomitant retroperitoneal lymph node dissection at mediastinal surgery. Results: Of the patients 60 (75%) are free of disease, 14 (18%) died of cancer and 6 (8%) are living with disease. Mediastinal pathology included teratoma in 65% of the patients, cancer in 26% and fibrosis in 9%. Of the 65 patients who underwent retroperitoneal lymph node dissection 75% had teratoma, 15% had fibrosis and 10% had cancer. Mediastinal relapses after dissection were rare (4 of 80 patients). Conclusions: Germ cell tumors metastatic to the mediastinum appear to behave similarly to those metastatic to the retroperitoneum. Primary mediastinal germ cell tumors have an entirely different clinical course. Teratoma is the predominant pathological type of post-chemotherapy germ cell cancer metastatic to the mediastinum.

Original languageEnglish
Pages (from-to)1345-1348
Number of pages4
JournalJournal of Urology
Volume156
Issue number4
StatePublished - Oct 1996

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Germ Cell and Embryonal Neoplasms
Mediastinum
Drug Therapy
Teratoma
Lymph Node Excision
Fibrosis
Neoplasms
Nonseminomatous germ cell tumor
Dissection
Databases
Pathology
Recurrence

Keywords

  • germ cells
  • mediastinal diseases
  • mediastinum
  • neoplasm metastasis
  • testicular neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Hejase, M. J., Donohue, J. P., Foster, R., Bihrle, R., Coogan, C. L., Rowland, R. G., & Wahle, G. R. (1996). Post-chemotherapy resection of nonseminomatous germ cell testicular tumors metastatic to the mediastinum. Journal of Urology, 156(4), 1345-1348.

Post-chemotherapy resection of nonseminomatous germ cell testicular tumors metastatic to the mediastinum. / Hejase, Mohamed J.; Donohue, John P.; Foster, Richard; Bihrle, Richard; Coogan, Christopher L.; Rowland, Randall G.; Wahle, Gregory R.

In: Journal of Urology, Vol. 156, No. 4, 10.1996, p. 1345-1348.

Research output: Contribution to journalArticle

Hejase, MJ, Donohue, JP, Foster, R, Bihrle, R, Coogan, CL, Rowland, RG & Wahle, GR 1996, 'Post-chemotherapy resection of nonseminomatous germ cell testicular tumors metastatic to the mediastinum', Journal of Urology, vol. 156, no. 4, pp. 1345-1348.
Hejase, Mohamed J. ; Donohue, John P. ; Foster, Richard ; Bihrle, Richard ; Coogan, Christopher L. ; Rowland, Randall G. ; Wahle, Gregory R. / Post-chemotherapy resection of nonseminomatous germ cell testicular tumors metastatic to the mediastinum. In: Journal of Urology. 1996 ; Vol. 156, No. 4. pp. 1345-1348.
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