Post-ERCP bleeding in the era of multiple antiplatelet agents

Hyoung Chul Oh, Ihab I. El Hajj, Jeffrey J. Easler, James Watkins, Evan Fogel, Lee McHenry, Glen Lehman, Jung Sik Choi, Hyun Kang, Stuart Sherman

Research output: Contribution to journalArticle

5 Scopus citations


Background/Aims: This study aimed to determine the risk of post-endoscopic retrograde cholangiopancreatography (post-ERCP) bleeding among patients taking antiplatelet agents (APAs), particularly in the era of multiple APAs. Methods: The primary outcomes were the frequency, type, and severity of ERCP-related bleeding according to the use of APAs. Results: The frequencies of post-ERCP bleeding among the four different groups were 16 of 2,083 (0.8%) in the no drug group, 12 of 256 (4.7%) in the aspirin group, 3 of 48 (6.3%) in the single APA group, and 4 of 48 (8.3%) in the multiple APA group (p<0.001). In the univariate analysis, post-ERCP bleeding was associated with age, pull-type sphincterotomy, and APA and was inversely associated with balloon dilation of the biliary orifice. In the multivariate analysis, pull-type sphincterotomy (odds ratio [OR], 7.829; 95% confidence interval [CI], 1.411 to 43.453; p=0.019) and country (Korea: OR, 0.124; 95% CI, 0.042 to 0.361; p<0.001) were associated with post-ERCP bleeding. Conclusions: The frequency of post-ERCP bleeding was statistically higher in patients on any APA within 6 days prior to ERCP. However, in the multivariate analysis, APA use was not associated with post-ERCP bleeding. Until a large, adequately powered study to detect differences is performed, caution is recommended when considering invasive procedures during ERCP in patients on APAs. (Gut Liver 2018;12:214-218).

Original languageEnglish (US)
Pages (from-to)214-218
Number of pages5
JournalGut and Liver
Issue number2
StatePublished - Mar 1 2018


  • Cholangiopancreatography
  • Endoscopic retrograde
  • Hemorrhage
  • Platelet aggregation inhibitors

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Post-ERCP bleeding in the era of multiple antiplatelet agents'. Together they form a unique fingerprint.

  • Cite this

    Oh, H. C., El Hajj, I. I., Easler, J. J., Watkins, J., Fogel, E., McHenry, L., Lehman, G., Choi, J. S., Kang, H., & Sherman, S. (2018). Post-ERCP bleeding in the era of multiple antiplatelet agents. Gut and Liver, 12(2), 214-218.