Post hoc analysis: Early changes in ADHD-RS items predict longer term response to atomoxetine in pediatric patients

Stan L. Block, David Williams, Craig L. Donnelly, David W. Dunn, Keith E. Saylor, Stephen J. Ruberg

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Data from 5 atomoxetine trials in pediatric outpatients with attention-deficit/hyperactivity disorder (ADHD) were divided into training and validation data sets to develop models predicting atomoxetine treatment response, using changes in individual ADHD Rating Scale (ADHD-RS) items early in treatment. Treatment response was predicted after 1 week by a ≥1-point score decrease in ADHD-RS item 15 ("easily distracted;" positive predictive values [PPVs]: 84.9%, 74.3%, and 73.3%; negative predictive values [NPVs]: 52.6%, 50.5%, and 46.3%; training and 2 validation data sets, respectively); after 2 to 3 weeks, by a ≥1-point score decrease in ADHD-RS item 1 ("fails to give close attention or makes careless mistakes;" PPV = 77.7% and 77.9%) and by the absence of a ≥1-point score decrease on ADHD-RS items 1 and 10 ("on the go;" NPV = 72.2% and 77.5%), or by the combination of items 1 and 10 (PPVs: 75.1% and 75.4%; NPVs: 72.2% and 77.5%; training and validation data sets, respectively).

Original languageEnglish (US)
Pages (from-to)768-776
Number of pages9
JournalClinical Pediatrics
Volume49
Issue number8
DOIs
StatePublished - Aug 1 2010

Keywords

  • ADHD-RS
  • CART
  • prediction
  • treatment response

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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