Post-transplant outcomes in pediatric ventricular assist device patients: A PediMACS–Pediatric Heart Transplant Study linkage analysis

David L. Sutcliffe, Elizabeth Pruitt, Ryan S. Cantor, Justin Godown, John Lane, Mark W. Turrentine, Sabrina P. Law, Jodie L. Lantz, James K. Kirklin, Daniel Bernstein, Elizabeth D. Blume

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background: Pediatric ventricular assist device (VAD) support as bridge to transplant has improved waitlist survival, but the effects of pre-implant status and VAD-related events on post-transplant outcomes have not been assessed. This study is a linkage analysis between the PediMACS and Pediatric Heart Transplant Study databases to determine the effects of VAD course on post-transplant outcomes. Methods: Database linkage between October 1, 2012 and December 31, 2015 identified 147 transplanted VAD patients, the primary study group. The comparison cohort was composed of 630 PHTS patients without pre-transplant VAD support. The primary outcome was post-transplant survival, with secondary outcomes of post-transplant length of stay, freedom from infection and freedom from rejection. Results: At implant, the VAD cohort was INTERMACS Profile 1 in 33 (23%), Profile 2 in 89 (63%) and Profile 3 in 14 (10%) patients. The VAD cohort was older, larger, and less likely to have congenital heart disease (p < 0.0001). However, they had greater requirements for inotrope and ventilator support and increased liver and renal dysfunction (p < 0.0001), both of which normalized at transplant after device support. Importantly, there were no differences in 1-year post-transplant survival (96% vs 93%, p = 0.3), freedom from infection (81% vs 79%, p = 0.9) or freedom from rejection (71% vs 74%, p = 0.87) between cohorts. Conclusions: Pediatric VAD patients have post-transplant outcomes equal to that of medically supported patients, despite greater pre-implant illness severity. Post-transplant survival, hospital length of stay, infection and rejection were not affected by patient acuity at VAD implantation or VAD-related complications. Therefore, VAD as bridge to transplant mitigates severity of illness in children.

Original languageEnglish (US)
Pages (from-to)715-722
Number of pages8
JournalJournal of Heart and Lung Transplantation
Volume37
Issue number6
DOIs
StatePublished - Jun 2018

Keywords

  • PHTS
  • PediMACS
  • Pediatric Heart Transplant Study
  • VAD
  • heart transplant
  • pediatric
  • ventricular assist device

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

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    Sutcliffe, D. L., Pruitt, E., Cantor, R. S., Godown, J., Lane, J., Turrentine, M. W., Law, S. P., Lantz, J. L., Kirklin, J. K., Bernstein, D., & Blume, E. D. (2018). Post-transplant outcomes in pediatric ventricular assist device patients: A PediMACS–Pediatric Heart Transplant Study linkage analysis. Journal of Heart and Lung Transplantation, 37(6), 715-722. https://doi.org/10.1016/j.healun.2017.12.004