Postnatal administration of D1 dopamine agonist reverses neonatal dopaminergic lesion-induced changes in striatal enkephalin and substance P systems

Subbiah Sivam, Jeffrey Cox

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The present study examined the effects of postnatal dopamine (DA) receptor stimulation on enkephalin (Met5-enkephalin; ME) and tachykinin (substance P; SP) systems of basal ganglia of rats, lesioned as neonates with 6-hydroxydopamine (6-OHDA, intracisternally) on the third postnatal day. D1 agonist, SKF-38393 or D2 agonist, LY-171555 (also known as quinpirole) was administered s.c. twice daily for 14 days, beginning 24 h after 6-OHDA administration. The animals were sacrificed at 60 days of age, and the concentrations of striatal DA, SP, and ME were determined by HPLC or radioimmunoassay. As expected, 6-OHDA induced a severe loss of DA, an increase in ME, and a decrease in SP. SKF-38393, but not, quinpirole significantly reversed the lesion-induced changes in ME and SP levels. The results indicate an important role for D1 receptors in the postnatal development of ME and SP systems in the striatum. These studies are relevant to our further understanding of potential early interventions in the progression and expression of DA deficiency states such as Parkinsonism and Lesch-Nyhan disease.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalBrain Research
Volume1073-1074
Issue number1
DOIs
StatePublished - Feb 16 2006

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Corpus Striatum
Enkephalins
Oxidopamine
Dopamine Agonists
Substance P
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Quinpirole
Dopamine
4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline
Lesch-Nyhan Syndrome
Tachykinins
Dopamine Receptors
Parkinsonian Disorders
Basal Ganglia
Radioimmunoassay
High Pressure Liquid Chromatography

Keywords

  • 6-Hydroxydopamine
  • D1 receptor
  • D2 receptor
  • Dopamine
  • LY-171555
  • Met5-enkephalin
  • SKF-38393
  • Substance P

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Postnatal administration of D1 dopamine agonist reverses neonatal dopaminergic lesion-induced changes in striatal enkephalin and substance P systems. / Sivam, Subbiah; Cox, Jeffrey.

In: Brain Research, Vol. 1073-1074, No. 1, 16.02.2006, p. 159-163.

Research output: Contribution to journalArticle

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