Postnatal maternal separation enhances tonic GABA current of cortical layer 5 pyramidal neurons in juvenile rats and promotes genesis of GABAergic neurons in neocortical molecular layer and subventricular zone in adult rats

Mei Feng, Guoxia Sheng, Zhongxia Li, Jiangping Wang, Keming Ren, Xiaoming Jin, Kewen Jiang

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Postnatal maternal separation (PMS) has been shown to be associated with an increased vulnerability to psychiatric illnesses in adulthood. However, the underlying neurological mechanisms are not well understood. Here we evaluated its effects on neurogenesis and tonic GABA currents of cortical layer 5 (L5) pyramidal neurons. PMS not only increased cell proliferation in the subventricular zone, cortical layer 1 and hippocampal dentate gyrus in the adult brain, but also promoted the newly generated cells to differentiate into GABAergic neurons, and PMS adult brain maintained higher ratios of GABAergic neurons in the survival of newly generated cells within 5 days immediately post PMS. Additionally, PMS increased the tonic currents at P7-10 and P30-35 in cortical L5 pyramidal cells. Our results suggest that the newly generated GABAergic neurons and the low GABA concentration-activated tonic currents may be involved in the development of psychiatric disorders after PMS.

Original languageEnglish (US)
Pages (from-to)74-82
Number of pages9
JournalBehavioural Brain Research
Volume260
DOIs
StatePublished - Mar 1 2014

Keywords

  • Cell fate decision
  • Cell proliferation
  • Postnatal maternal separation
  • Tonic GABA current

ASJC Scopus subject areas

  • Behavioral Neuroscience

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