Postpartum intracranial venous thrombosis associated with dysfunctional protein C and deficiency of protein S

Karen Roos, Robert Pascuzzi, Michael A. Kuharik, Amy D. Shapiro, Marilyn J. Manco-Johnson

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Development of intracranial dural sinus thrombosis in the postpartum period has been attributed to the hypercoagulable state of pregnancy. With increasing recognition of the role of the vitamin K-dependent proteins, protein C and protein S, in intracranial venous and arterial thrombotic events, our understanding of the cause of thrombotic events has improved. We report a patient who developed a superior sagittal sinus thrombosis in the second week postpartum, associated with a dysfunctional protein C and a decreased free protein S concentration.

Original languageEnglish
Pages (from-to)492-494
Number of pages3
JournalObstetrics and Gynecology
Volume76
Issue number3
StatePublished - 1990

Fingerprint

Protein C Deficiency
Intracranial Thrombosis
Protein S
Protein C
Venous Thrombosis
Postpartum Period
Sagittal Sinus Thrombosis
Superior Sagittal Sinus
Intracranial Sinus Thrombosis
Vitamin K
Pregnancy
Proteins

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Postpartum intracranial venous thrombosis associated with dysfunctional protein C and deficiency of protein S. / Roos, Karen; Pascuzzi, Robert; Kuharik, Michael A.; Shapiro, Amy D.; Manco-Johnson, Marilyn J.

In: Obstetrics and Gynecology, Vol. 76, No. 3, 1990, p. 492-494.

Research output: Contribution to journalArticle

Roos, Karen ; Pascuzzi, Robert ; Kuharik, Michael A. ; Shapiro, Amy D. ; Manco-Johnson, Marilyn J. / Postpartum intracranial venous thrombosis associated with dysfunctional protein C and deficiency of protein S. In: Obstetrics and Gynecology. 1990 ; Vol. 76, No. 3. pp. 492-494.
@article{10dd756c24404879a3f121bad1b1e754,
title = "Postpartum intracranial venous thrombosis associated with dysfunctional protein C and deficiency of protein S",
abstract = "Development of intracranial dural sinus thrombosis in the postpartum period has been attributed to the hypercoagulable state of pregnancy. With increasing recognition of the role of the vitamin K-dependent proteins, protein C and protein S, in intracranial venous and arterial thrombotic events, our understanding of the cause of thrombotic events has improved. We report a patient who developed a superior sagittal sinus thrombosis in the second week postpartum, associated with a dysfunctional protein C and a decreased free protein S concentration.",
author = "Karen Roos and Robert Pascuzzi and Kuharik, {Michael A.} and Shapiro, {Amy D.} and Manco-Johnson, {Marilyn J.}",
year = "1990",
language = "English",
volume = "76",
pages = "492--494",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Postpartum intracranial venous thrombosis associated with dysfunctional protein C and deficiency of protein S

AU - Roos, Karen

AU - Pascuzzi, Robert

AU - Kuharik, Michael A.

AU - Shapiro, Amy D.

AU - Manco-Johnson, Marilyn J.

PY - 1990

Y1 - 1990

N2 - Development of intracranial dural sinus thrombosis in the postpartum period has been attributed to the hypercoagulable state of pregnancy. With increasing recognition of the role of the vitamin K-dependent proteins, protein C and protein S, in intracranial venous and arterial thrombotic events, our understanding of the cause of thrombotic events has improved. We report a patient who developed a superior sagittal sinus thrombosis in the second week postpartum, associated with a dysfunctional protein C and a decreased free protein S concentration.

AB - Development of intracranial dural sinus thrombosis in the postpartum period has been attributed to the hypercoagulable state of pregnancy. With increasing recognition of the role of the vitamin K-dependent proteins, protein C and protein S, in intracranial venous and arterial thrombotic events, our understanding of the cause of thrombotic events has improved. We report a patient who developed a superior sagittal sinus thrombosis in the second week postpartum, associated with a dysfunctional protein C and a decreased free protein S concentration.

UR - http://www.scopus.com/inward/record.url?scp=0025171636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025171636&partnerID=8YFLogxK

M3 - Article

C2 - 2143277

AN - SCOPUS:0025171636

VL - 76

SP - 492

EP - 494

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 3

ER -